Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Otology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1515953

Analysis of clinical characteristics and predictive model for effective treatment of tinnitus in patients with transient compound sound therapy

Provisionally accepted
Hao Yuan Hao Yuan Peng-Wei Ma Peng-Wei Ma Jiawei Chen Jiawei Chen Wang Weilong Wang Weilong Wei Gao Wei Gao Pei-Heng Lu Pei-Heng Lu Xue-Rui Ding Xue-Rui Ding Yuqiang Lun Yuqiang Lun Zi Wang Zi Wang Lu Lianjun Lu Lianjun *
  • Department of Otorhinolaryngology Head and Neck Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China

The final, formatted version of the article will be published soon.

    This study explored the clinical characteristics of patients with tinnitus who responded to sound therapy and established a predictive model to evaluate the effectiveness of this therapy according to the clinical characteristics.A retrospective analysis was performed on 991 subjective tinnitus patients who received compound sound therapy in the Department of Otolaryngology of the local hospital from November 2019 to January 2022.We found that tinnitus patients with different therapeutic effects had significant differences in the tinnitus side (P=0.007), tone loudness distortion feedback test (FBT) (P=0.000), residual inhibition test (RIT) (P=0.000), tinnitus frequency (P=0.012) and sensation level (P=0.023). The corresponding variables were screened by univariate logistic regression, and the selected variables were analyzed using multivariate logistic regression. The results showed that FBT (P=0.003), RIT (P=0.000) and tinnitus frequency (P=0.029) were independent risk factors affecting the efficacy of compound sound therapy. A predictive model and nomogram for the efficacy of compound sound therapy for tinnitus were constructed based on independent risk factors. The area under the curve (AUC) of the model constructed in this study was 0.766(95% CI=0.725-0.807), indicating a certain prediction ability. The calibration curve revealed that the predicted results were in good agreement with the actual results.The model can predict the prognosis of tinnitus in patients receiving compound sound therapy and help otolaryngologists make the best clinical decisions regarding tinnitus treatment.

    Keywords: Tinnitus, Sound therapy, prognosis, outcome prediction, nomogram

    Received: 23 Oct 2024; Accepted: 26 Nov 2024.

    Copyright: © 2024 Yuan, Ma, Chen, Weilong, Gao, Lu, Ding, Lun, Wang and Lianjun. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lu Lianjun, Department of Otorhinolaryngology Head and Neck Surgery, Tangdu Hospital, Air Force Medical University, Xi'an, Shaanxi Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.