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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Applied Neuroimaging
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1513896

Metabolic changes of thalamus assessed by 1 H-MRS spectroscopy in patients of cervical spondylotic myelopathy following decompression surgery

Provisionally accepted
Jiangqin Zheng Jiangqin Zheng 1Yujin Zhang Yujin Zhang 2*Baogen Zhao Baogen Zhao 2*Ning Wang Ning Wang 2*Ting Gao Ting Gao 2*Li Zhang Li Zhang 2*
  • 1 Department of Radiology, Hainan Maternal and Child Health Hospital, Haikou, China
  • 2 The First hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Objective To assess the changes of thalamic metabolites before and after surgery in patients with Cervical Spondylotic Myelopathy (CSM) using Hydrogen Proton Magnetic Resonance Spectroscopy ( 1 H-MRS) and to investigate its association with improvement in neurological function.Methods Forty-eight CSM patients who underwent cervical decompression surgery from December 2022 to June 2023 were included, and 33 healthy volunteers were recruited. All subjects underwent bilateral thalamic 1 H-MRS scans before the surgical procedure, and subsequently again six months later. Neurological function was assessed pre-operatively and post-operatively (six months) in all patients with CSM using the modified Japanese Orthopaedic Association (mJOA). The changes of mJOA (△mJOA=postoperative mJOA -preoperative mJOA) were employed as an indicator of neurological improvement. The pre-and postoperative metabolic ratio of N-acetylaspartate/creatine (NAA/Cr), choline/creatine (Cho/Cr), myo-inositol /creatine (mI/Cr), glutamate and glutamine complex/creatine (Glx/Cr) were statistically compared in CSM patients and healthy controls (HCs). A correlation analysis was conducted to determine the relationship between alterations in pre-and postoperative metabolite ratios (△NAA/Cr, △Cho/Cr, △mI/Cr, △Glx/Cr) and ΔmJOA.Compared to the HCs, patients with CSM showed significantly lower pre-and post-operative NAA/Cr (t = -4.988, P < 0.001; t = -3.562, P = 0.001), Cho/Cr

    Keywords: Cervical spondylotic myelopathy, Magnetic Resonance Spectroscopy, Thalamus, Modified Japanese Orthopaedic Association, postoperative

    Received: 19 Oct 2024; Accepted: 12 Dec 2024.

    Copyright: © 2024 Zheng, Zhang, Zhao, Wang, Gao and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yujin Zhang, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Baogen Zhao, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Ning Wang, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Ting Gao, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China
    Li Zhang, The First hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei Province, China

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