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STUDY PROTOCOL article

Front. Neurol.
Sec. Applied Neuroimaging
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1511767
This article is part of the Research Topic Advanced fNIRS Applications in Neuroscience and Neurological Disorders View all 6 articles

Differences in the effect of repetitive transcranial magnetic stimulation and median nerve electrical stimulation on the level of consciousness in patients with prolonged disorders of consciousness after intracerebral haemorrhage: a randomized controlled trial protocol

Provisionally accepted
Guoshun Zhao Guoshun Zhao Mingzhu Fang Mingzhu Fang *Shiyu Han Shiyu Han *Xiaoke Peng Xiaoke Peng *Anqin Dong Anqin Dong *
  • Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Background: Repetitive transcranial magnetic stimulation(rTMS) and median nerve electrical stimulation (MNES) are two non-invasive neuromodulation techniques that have demonstrated potential in facilitating the recovery of consciousness in patients with impaired consciousness.However, existing studies on awakening interventions for patients with prolonged disorders of consciousness (pDoC) following intracerebral hemorrhage remains limited. In particular, systematic comparisons of the efficacy of rTMS versus MNES in this specific patient population are lacking.Methods: This is a single-center randomized controlled trial in which 45 patients will be randomly assigned to the control group, rTMS group and MNES group. The intervention period will lasts 4 weeks. All patients underwent multimodal assessments before and at the end of treatment, which were used to comprehensively evaluate their recovery of consciousness and changes in brain function.The assessments includes the Coma Recovery Scale, electroencephalogram, event-related potentials (P300 and mismatched negative) and functional near-infrared spectroscopy.Discussion: This study represents the first systematic comparison of the efficacy between rTMS and MNES in patients with pDoC following intracerebral hemorrhage. The objective is to employ multimodal assessment techniques to provide clinical references into the individualized application of these neuromodulation therapies.The trial was registered in the Chinese Clinical Trial Registry (https://www.chictr.org.cn/ , Registration No. ChiCTR2400082022).

    Keywords: Prolonged Disorders of consciousness, Median nerve electrical stimulation, repetitive transcranial magnetic stimulation, EEG, functional near infrared spectroscopy

    Received: 15 Oct 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Zhao, Fang, Han, Peng and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Mingzhu Fang, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
    Shiyu Han, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
    Xiaoke Peng, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China
    Anqin Dong, Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.