Lu Hong Juan
1
Yang Haoran
1*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Neurol.
Sec. Epilepsy
Volume 15 - 2024 |
doi: 10.3389/fneur.2024.1510108
This article is part of the Research Topic Advances in Epilepsy Research: Exploring Biomarkers, Brain Stimulation, and Neurosurgical Interventions View all 5 articles
An ictogenic marker in the mesial temporal epilepsy and its temporal evolutionary features
Provisionally accepted- 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
- 2 Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
Objective: To observe and measure the morphological and temporal evolutionary features of the hypersynchronous (HYP) pattern in the mesial temporal seizure.The HYP patterns during preictal and interictal states of 16 mesial temporal epileptic patients were analyzed. The wave components of the HYP transients were firstly observed and measured. The dynamic deformations and parameter changes of the components were further analyzed along the preictal-ictal axis. The difference of emergence rate of HYP transients and typical interictal spike during interictal periods was also compared.The HYP transients were invariably composed of slow-wave proper, sharp wave and postslow component among studied patients for all the 93 seizures. During preictal epoch, all of the seizures incorporated present evolutionary manner of type 1 characterized by smooth modification of HYP transients in morphology, including gradual shortening of the inter-transient interval, increase of amplitude and time duration of slow-wave proper and sharp wave, amplitude decrease of the post-slow component, as well as amplitude increases of ripple and fast ripple, and 2/3 seizures showed some more sophisticated transitional manners (type 2) following type 1, including reduction in amplitude with decrease of inter-transient intervals, superimposed or followed by the emergent low amplitude rhythmic activities, or both of them. The HYP transients and typical interictal spikes were found to mutually "repelling" each other in interictal period.The HYP transients showed a combinational feature and temporal evolution manners during preictal state. The emergence of HYP transients in cluster reflects the transitional trend from interictal to ictal state.Significance: HYP should be viewed as an index of ictogenesis in the mesial temporal seizure.
Keywords: Hypersynchronous pattern, Meisal temporal seizure, Ictogensis, Dynamic evolution, Preictal changes
Received: 12 Oct 2024; Accepted: 26 Dec 2024.
Copyright: © 2024 Hong Juan, Haoran, Wei, Xingzhou and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yang Haoran, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
Zhang Wei, Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
Liu Xingzhou, Department of Neurology, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China
Sun Wei, Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China
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