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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1509845
This article is part of the Research Topic The association between the nervous system and the stomatognathic system: from etiology to diagnosis and treatment of orofacial pain View all articles

Oxidative imbalance as a co-player in jaw functional limitations and biopsychosocial profile in patients with temporomandibular disordermyofascial pain with referral

Provisionally accepted
Joanna Kuć Joanna Kuć 1,2*Krzysztof Dariusz Szarejko Krzysztof Dariusz Szarejko 3Mateusz Maciejczyk Mateusz Maciejczyk 4Violetta Dymicka- Piekarska Violetta Dymicka- Piekarska 5Małgorzata Żendzian-Piotrowska Małgorzata Żendzian-Piotrowska 4Anna Zalewska Anna Zalewska 6
  • 1 Medical University of Bialystok, Bialystok, Poland
  • 2 Department of Prosthodontics, Medical University of Bialystok, Bialystok, Poland
  • 3 Private Health Care, Physical Therapy and Rehabilitation, Białystok, Podlaskie, Poland
  • 4 Department of Hygiene, Epidemiology and Ergonomics, Medical University of Bialystok,, Bialystok, Poland
  • 5 Department of Clinical Laboratory Diagnostics, Medical Univeristy of Bialystok, Bialystok, Poland
  • 6 Independent Laboratory of Experimental Dentistry, Medical University of Bialystok,, Bialystok, Poland

The final, formatted version of the article will be published soon.

    Introduction: Temporomandibular disorders have a multifactorial etiology including biological, biomechanical, neuromuscular and biopsychosocial factors. Current research on temporomandibular disorders focuses on identifying clinically relevant biomarkers thus creating a new way of thinking about this dysfunction. The aim of the study was to determine relationship between salivary/blood concentrations of oxidative/nitrosative stress biomarkers and biopsychosocial findings in patients with temporomandibular disorder - myofascial pain with referral. Methods: The sample enrolled a total of 26 individuals with temporomandibular myofascial pain with referral (20 females, 6 males). The procedure included clinical examination according to the Diagnostic Criteria for Temporomandibular Disorders, saliva and blood collection. Biochemical analysis concerned, among others, the content of reduced glutathione, uric acid, total antioxidant capacity, advanced glycation end products, malondialdehyde, total lipid hydroperoxides, kynurenine, N-formylkynurenine and peroxynitrite. All determinations were considered with respect to the Patient Health Questionnaire-4 (PHQ-4), Patient Health Questionnaire-9 (PHQ-9), Patient Health Questionnaire-15 (PHQ-15), Generalized Anxiety Disorder-7 (GAD-7), Jaw Functional Limitation Scale-20 (JFLS-20), Perceived Stress Scale-10 (PSS-10) and Beck Depression Inventory (BDI). Results and discussion: The average age of participants was 24.2 ± 1.23. High content of kynurenine and N-formylkynurenine in plasma were related to intensified psychological distress (PHQ-4) and anxiety (GAD-7). Low concentration of plasma malondialdehyde and total lipid hydroperoxides linked with severe somatization (PHQ-15) and stress (PSS-10), respectively. Reduced levels of non-enzymatic antioxidants were associated with greater jaw functional mobility restrictions as well as limited mastication and communication factor with respect to JFLS-20. These findings indicates that oxidative stress biomarkers are significantly related to the biopsychosocial profile in patients with temporomandibular disorder.

    Keywords: antioxidants1, biomarkers2, biopsychosocial profile3, myofascial pain with referral4, orofacial pain5, stomatognathic system6, temporomandibular disorders6

    Received: 11 Oct 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Kuć, Szarejko, Maciejczyk, Dymicka- Piekarska, Żendzian-Piotrowska and Zalewska. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Joanna Kuć, Medical University of Bialystok, Bialystok, Poland

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.