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REVIEW article

Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1505879
This article is part of the Research Topic Synaptic Health as a Prognostic Tool in Alzheimer's and Related Dementias View all 4 articles

IMPACT OF PHYSICAL EXERCISE ON THE REGULATION OF BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) AND ITS RELEVANCE IN NEURODEGENERATIVE

Provisionally accepted
Ana Romero Garavito Ana Romero Garavito 1Valery Díaz Martínez Valery Díaz Martínez 1Esther Juárez Cortés Esther Juárez Cortés 2José Vicente Negrete Díaz José Vicente Negrete Díaz 2Liliana Marcela Montilla Rodríguez Liliana Marcela Montilla Rodríguez 1*
  • 1 Facultad de medicina. Universidad Cooperativa de Colombia., Villavicencio, Colombia
  • 2 University of Guanajuato, Guanajuato, Guanajuato, Mexico

The final, formatted version of the article will be published soon.

    This review examines the effect of physical exercise on brain-derived neurotrophic factor (BDNF) and its association with neurodegenerative diseases. The importance of BDNF in brain health is highlighted, and recent studies are reviewed that show an increase in BDNF following exercise, particularly in young adults. Additionally, the interaction between the BDNF Val66Met genetic polymorphism and exercise on cognitive function is discussed. This review emphasizes the potential of exercise as a complementary therapy for neurodegenerative diseases, although further research is needed to fully understand its effects.

    Keywords: physical exercise, Brain-derived neurotrophic factor (BDNF), Neurodegenerative Diseases, Dementia, Parkinson's disease, neuroplasticity

    Received: 03 Oct 2024; Accepted: 13 Dec 2024.

    Copyright: © 2024 Romero Garavito, Díaz Martínez, Juárez Cortés, Negrete Díaz and Montilla Rodríguez. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Liliana Marcela Montilla Rodríguez, Facultad de medicina. Universidad Cooperativa de Colombia., Villavicencio, Colombia

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.