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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Pediatric Neurology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1497969

Effectiveness and safety Analysis of Ketogenic Diet Therapy for Drug resistant Epilepsy Caused by Structural Pathology

Provisionally accepted
Song Su Song Su Hongwei Zhang Hongwei Zhang Huan Zhang Huan Zhang Yong Liu Yong Liu Guohua Liu Guohua Liu *
  • Children's Hospital Affiliated to Shandong University, Ji nan, China

The final, formatted version of the article will be published soon.

    Objective: To explore the effectiveness and safety of the ketogenic diet (KD) in children with drug resistant epilepsy (DRE) caused by structural etiology. Methods: The children were categorized into acquired brain injury group and malformations of cortical development (MCD) group based on the etiology. Follow-up assessments were performed at 1, 3, and 6 months after KD treatment to observe seizure reduction, behavioral and cognitive improvements, adverse reactions events, and reasons for discontinuation withdrawal. Statistical analysis was conducted on the results. Results: We found the seizure-free rates at 1, 3, and 6 months were 4.8% (2/42), 19% (8/42), and 21.4% (9/42), respectively. The seizure control effective rates were 42.9% (18/42), 52.4% (22/42), and 54.8% (23/42) at the corresponding time points. Compared to the acquired brain injury group, the MCD group showed a higher seizure control effective rate. Further analysis within the MCD group revealed the highest efficacy in focal cortical dysplasia (FCD). At the 3-month follow-up, cognitive and behavioral improvements were observed in 69% (29/42) of children. The main reasons for discontinuation were lack of efficacy and poor compliance. Significance: Finally, we get that KD is a safe and effective treatment for drug resistant epilepsy caused by structural etiology, with the added benefit of improving behavioral and cognitive abilities in children. The efficacy is higher in children with MCD, particularly in cases of FCD. Early intervention with KD is recommended for this population.

    Keywords: Drug resistant epilepsy FCD, Focal cortical dysplasia KDT, Ketogenic diet therapy MCT, Medium-chain triglyceride MAD, Modified Atkins diet LGIT, Low glycemic index treatment ASMs, Anti-seizure medications HIE, Hypoxic-ischemic encephalopathy MCD

    Received: 18 Sep 2024; Accepted: 16 Oct 2024.

    Copyright: © 2024 Su, Zhang, Zhang, Liu and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Guohua Liu, Children's Hospital Affiliated to Shandong University, Ji nan, China

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