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SYSTEMATIC REVIEW article

Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1496871
This article is part of the Research Topic Blood, Cerebrospinal Fluid, and Vascular Biomarkers for Dementia View all 7 articles

The triglyceride-glucose index and risk of cognitive impairment: A systematic review and meta-analysis with inclusion of two national databases

Provisionally accepted
Ying Yang Ying Yang 1Pai Peng Pai Peng 2*Huadong Huang Huadong Huang 2*Yanan Zhao Yanan Zhao 2*Yating Li Yating Li 2*Xiao Xu Xiao Xu 3*Shixie Jiang Shixie Jiang 4Yanrong Yang Yanrong Yang 1Gaofeng Pan Gaofeng Pan 1*Yanting Wen Yanting Wen 1DAN WU DAN WU 5Shanping Chen Shanping Chen 1*Feng Lei Feng Lei 1Tangming PENG Tangming PENG 1Jiang Wang Jiang Wang 2*Zheng Li Zheng Li 1*
  • 1 Chengdu Fifth People's Hospital, Chengdu, China
  • 2 Jinggangshan University, Ji'an, Jiangxi Province, China
  • 3 Tongji University, Shanghai, Shanghai Municipality, China
  • 4 College of Medicine, University of Florida, Gainesville, Florida, United States
  • 5 Chongqing University of Postsand Telecommunications, Chongqing, China

The final, formatted version of the article will be published soon.

    Background To investigate the relationship between the triglyceride and glucose (TyG) index and cognitive impairment (CI). Methods Five authoritative databases were systematically searched for potentially relevant studies on ‘TyG index’ and ‘CI’ from inception to 27 April 2024. Two representative databases from the U.K. and U.S.A. were also included. We used the PICOS criteria to select available articles. All data was combined to compute Odd Ratios (ORs). Results 15 studies were included in the meta-analysis (participants:5604303). The pooled effect sizes demonstrate that individuals with a high TyG index exhibit a significantly elevated risk of CI compared to those with a low TyG index. (OR=2.16, 95%CI:1.51;3.08, p<0.001). The subgroup analysis showed that inpatients with a high TyG index exhibited an increased risk of CI (OR=4.56, 95%CI:3.09; 6.74, p<0.001). Furthermore, the risk of developing distinct types of CI differed significantly (CI: OR=1.64, 95% CI:1.29;2.07, p<0.001(1, 30, 32, 33, 36, 38, 41, 46); Vascular Cognitive Impairment(VCI): OR=5.39, 95% CI:3.33;8.70, p<0.001(31, 43)). Conclusions A positive correlation exists between the TyG index and risk of CI, which has potential value in optimizing CI risk stratification among elderly people, especially those hospitalized. Key Words The triglyceride and glucose (TyG) index, Cognitive impairment(CI), Prevalence, Elderly people， Inpatients.

    Keywords: The triglyceride and glucose (TyG) index, cognitive impairment(CI), Prevalence, Elderly people， Inpatients, Vascular Cognitive Impairment(VCI)

    Received: 15 Sep 2024; Accepted: 15 Nov 2024.

    Copyright: © 2024 Yang, Peng, Huang, Zhao, Li, Xu, Jiang, Yang, Pan, Wen, WU, Chen, Lei, PENG, Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Pai Peng, Jinggangshan University, Ji'an, 343009, Jiangxi Province, China
    Huadong Huang, Jinggangshan University, Ji'an, 343009, Jiangxi Province, China
    Yanan Zhao, Jinggangshan University, Ji'an, 343009, Jiangxi Province, China
    Yating Li, Jinggangshan University, Ji'an, 343009, Jiangxi Province, China
    Xiao Xu, Tongji University, Shanghai, 200092, Shanghai Municipality, China
    Gaofeng Pan, Chengdu Fifth People's Hospital, Chengdu, China
    Shanping Chen, Chengdu Fifth People's Hospital, Chengdu, China
    Jiang Wang, Jinggangshan University, Ji'an, 343009, Jiangxi Province, China
    Zheng Li, Chengdu Fifth People's Hospital, Chengdu, China

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