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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Epilepsy
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1496507
This article is part of the Research Topic Prevention of and early intervention for behavioral health disorders in people with epilepsy View all 3 articles

Circadian rhythm and epilepsy: a nationally representative crosssectional study based on actigraphy data

Provisionally accepted
Tianyou Tang Tianyou Tang 1Xuan Zhai Xuan Zhai 1,2*
  • 1 Department of Neurosurgery, Children‘s Hospital of Chongqing Medical University, Chongqing, Chongqing Municipality, China
  • 2 Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China

The final, formatted version of the article will be published soon.

    Objective The study aims to assess the relationship between epilepsy and circadian rhythms. Method This study included a cohort of 7410 participants sourced from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) database. The investigation focused on the comparative analysis of seven nonparametric indices associated with circadian rhythms (Interdaily Stability (IS), Intradaily Variability (IV), Relative Amplitude (RA), L5, M10, L5 start time, and M10 start time) between the overall population and patients with epilepsy. Logistic regression analysis was utilized to assess the potential correlation between the rest-activity circadian rhythm patterns and the presence of epilepsy within the cohort. Results Compared to the general population, individuals with epilepsy exhibited lower values of IS and M10. Multivariable logistic regression analysis, when IS, RA, and M10 were categorized into four groups based on quartiles, revealed that the odds ratio (IS: OR = 0.36, 95% CI: 0.13, 0.89; RA: OR = 0.25, 95% CI: 0.06, 0.77; M10: OR = 0.24, 95% CI: 0.06, 0.73) for the highest quartile was lower than that for the lowest quartile. Furthermore, after adjustment for confounding factors, participants in the highest quartile compared to those in the lowest quartile of IV and M10 start time demonstrated a higher prevalence of epilepsy. Conclusions Individuals with epilepsy demonstrate significant alterations in circadian rhythms.

    Keywords: NHANES: National Health and Nutrition Examination Survey IS: Interdaily Stability IV: Intradaily Variability RA: Relative Amplitude ASM: Antiseizure medications RCS: Restricted cubic spline Epilepsy, Circadian Rhythm, NHANES, Epilepsy, Cross-seccional study

    Received: 14 Sep 2024; Accepted: 31 Oct 2024.

    Copyright: © 2024 Tang and Zhai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xuan Zhai, Ministry of Education Key Laboratory of Child Development and Disorders, Children's Hospital of Chongqing Medical University, Chongqing, China

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