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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Otology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1495893

Middle Ear Biofilm and Sudden Deafness A Light and Transmission Electron Microscopy Study

Provisionally accepted
Hao Li Hao Li 1,2Karin Staxäng Karin Staxäng 3Hanif Ladak Hanif Ladak 4,5Sumit Agrawal Sumit Agrawal 4,5,6Helge Rask-Andersen Helge Rask-Andersen 1,2*
  • 1 Uppsala University, Uppsala, Uppsala, Sweden
  • 2 Department of Surgical Sciences, Faculty of Medicine, Uppsala University, Uppsala, Uppsala, Sweden
  • 3 Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Faculty of Medicine, Uppsala University, Uppsala, Uppsala, Sweden
  • 4 Western University, London, Ontario, Canada
  • 5 Department of Electrical and Computer Engineering, Faculty of Engineering, Western University, London, Ontario, Canada
  • 6 Department of Otolaryngology – Head and Neck Surgery, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada

The final, formatted version of the article will be published soon.

    Human cochleae were collected during surgery via a trans-cochlear approach for posterior cranial fossa meningioma that had reached the clivus anteriorly. The study of human cochleae was approved by the local ethics committee (Etikprövningsnämnden Uppsala, no. 99398, 22/9 1999, cont, 2003, no. C254/4; no. C45/7 2007, Dnr. 2013/190), and patient consent was obtained. The study adhered to the rules of the Declaration of Helsinki. Cadaveric samples used for SR-PCI were obtained with permission from the body bequeathal Middle Ear Biofilm and Sensorineural Deafness program at Western University (London, ON, Canada) in accordance with the Anatomy Act of Ontario and Western's Committee for Cadaveric Use in Research (Approval # 122611).

    Keywords: human, Round window, Biofilm, occult infection, synchrotron phase-contrast imaging, sudden deafness

    Received: 25 Sep 2024; Accepted: 18 Nov 2024.

    Copyright: © 2024 Li, Staxäng, Ladak, Agrawal and Rask-Andersen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Helge Rask-Andersen, Department of Surgical Sciences, Faculty of Medicine, Uppsala University, Uppsala, SE-751 85, Uppsala, Sweden

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