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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1489430
This article is part of the Research Topic Alterations in brain structure, function and cognitive abilities caused by cerebrovascular diseases View all 4 articles

Low hemoglobin is associated with postoperative cerebral infarction of moyamoya disease: Development of a Predictive Model based on low hemoglobin

Provisionally accepted
Luo Li Luo Li 1*Haitao Wu Haitao Wu 2Tingxuan Wang Tingxuan Wang 2Fangbao Li Fangbao Li 3Yue Bao Yue Bao 1Yue Bao Yue Bao 1
  • 1 Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China
  • 2 Qingdao University Medical College, Qingdao, Shandong Province, China
  • 3 Dalian Medical University, Dalian, Liaoning, China

The final, formatted version of the article will be published soon.

    Background: Anemia is considered a risk factor for cardiovascular disease. However, there is little evidence regarding the relationship between hemoglobin (HB) and cerebral infarction after revascularization in patients with moyamoya disease (MMD). This study aimed to explore the relationship between postoperative cerebral infarction and HB in patients with MMD and to establish a predictive model. Methods: Demographic information and different HB (the preoperative and postoperative HB, highest and lowest HB, and mean HB during hospitalization) of 112 patients with MMD were collected, of which 11 had cerebral infarction after revascularization. Result: In the binomial logistic regression analysis, low HB level was an independent risk factor for cerebral infarction after revascularization, which also led to a worse long-term prognosis in patients with MMD. The risk factors Pre HB, Post HB, type of MMD, and HTN were introduced into the receiver operating characteristic curve with an area under the curve (AUC) of 0.83. Conclusion: The prediction model was visualized using a nomogram and a clinical decision curve was drawn to evaluate the net benefit of clinical decisions.

    Keywords: Moyamoya Disease, haemoglobin, Revascularization, postoperative cerebral infarction, Prediction model

    Received: 02 Sep 2024; Accepted: 02 Dec 2024.

    Copyright: © 2024 Li, Wu, Wang, Li, Bao and Bao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Luo Li, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.