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REVIEW article

Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1479197
This article is part of the Research Topic Neurocognitive Dysfunction in People Living with HIV and the Underlying Brain Mechanisms View all articles

Application status and prospects of multimodal EEG-fMRI in HIVassociated neurocognitive disorders

Provisionally accepted
Junzhuo Chen Junzhuo Chen 1Haixia Luo Haixia Luo 1Jiaojiao Liu Jiaojiao Liu 1Wei Wang Wei Wang 1Juming Ma Juming Ma 2Chuanke Hou Chuanke Hou 1Xingyuan Jiang Xingyuan Jiang 1Zhongkai Zhou Zhongkai Zhou 1Hongjun Li Hongjun Li 1*
  • 1 Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China
  • 2 Department of Radiology, Qilu Hospital of Shandong University, Jinan, China

The final, formatted version of the article will be published soon.

    HIV-associated neurocognitive disorders (HAND) are one of the common complications in people living with HIV (PLWH), which can affect their attention, working memory, and other related cognitive functions. With the widespread use of combination antiretroviral therapy (cART), the incidence of HAND has declined. However, HAND is still an important complication of HIV, which not only affects the quality of life of patients but also affects their adherence to HIV treatment. Its diagnosis mainly relies on neurocognitive tests, which have a certain degree of subjectivity, making it difficult to diagnose and classify HAND accurately, and there is an urgent need to explore more sensitive biomarkers. Multimodal brain imaging has seen a surge in recent years with simultaneous EEG-fMRI being at the forefront of cognitive multimodal neuroimaging. It is a complementary fusion technique that effectively combines the high spatial resolution of fMRI with the high temporal resolution of EEG, compensating for the shortcomings of a single technique and providing a new method for studying cognitive function. It is expected to reveal the underlying mechanisms of HAND and provide high spatiotemporal warning biomarkers of HAND, which will provide a new perspective for the early diagnosis and treatment of HAND and contribute to the improvement of patient prognosis.

    Keywords: Hand, EEG, fMRI, simultaneous EEG-fMRI, Multimodal Imaging

    Received: 11 Aug 2024; Accepted: 22 Nov 2024.

    Copyright: © 2024 Chen, Luo, Liu, Wang, Ma, Hou, Jiang, Zhou and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hongjun Li, Department of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.