Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Endovascular and Interventional Neurology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1474857

Quantitative hemodynamics of draining veins in brain arteriovenous malformation: a preliminary study based on computational fluid dynamics

Provisionally accepted
Ma Long Ma Long 1Yu Chen Yu Chen 1Pingting Chen Pingting Chen 2Li Ma Li Ma 1Debin Yan Debin Yan 1Ruinan Li Ruinan Li 1Zhipeng Li Zhipeng Li 1Haibin Zhang Haibin Zhang 1Heze Han Heze Han 1Kexin Yuan Kexin Yuan 1Runting Li Runting Li 1Fa Lin Fa Lin 1Yuanli Zhao Yuanli Zhao 3,4XiaoLin Chen XiaoLin Chen 5*
  • 1 Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
  • 2 College of Energy and Power Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, Liaoning Province, China
  • 3 Department of Neurosurgery, Peking University International Hospital, Peking University, Beijing, China
  • 4 Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  • 5 Beijing Tiantan Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    This study initiated a preliminary computational fluid dynamics (CFD)-based study to investigate the relationship between quantitative hemodynamics of arteriovenous malformation (AVM) draining veins and rupture.The quantitative hemodynamics of AVM draining veins were generated from computed tomography angiography (CTA)-based steady-state CFD models. Morphological and hemodynamic parameters were compared between the ruptured and unruptured groups. The boundary conditions of the drainage vein were obtained from quantitative digital subtraction angiography (QDSA). The draining veins were divided into 15 consecutive segments to analyze the spatial distribution of the hemodynamic parameters by linear regression analysis.From 11 AVMs, it was revealed that morphological parameters of drainage veins in ruptured and unruptured AVMs were similar. The intravascular pressure of the draining vein in the ruptured AVMs was significantly higher than those of the unruptured AVMs (pressure average: P=0.006; pressure maximum: P=0.045), and the WSS of the posterior segment was higher in ruptured AVMs (P=0.045).WSS of draining veins in ruptured AVMs showed a linear increase trend with segmenting (R=0.731, P<0.001), and ruptured AVMs were more likely to be accompanied by high-velocity segments in the draining vein (40.0% vs. 14.7%, P=0.037), especially in the posterior segment (P=0.011).The draining veins of ruptured AVMs had significantly higher intravascular pressure and posterior segment WSS. WSS showed a linear increase with segmentation in ruptured AVMs, and they often had more high-velocity segments in the draining vein, especially in the posterior segment.

    Keywords: arteriovenous malformation, hemodynamic, Angioarchitecture, computational fluid dynamics, Wall shear stress；Pressure

    Received: 02 Aug 2024; Accepted: 28 Nov 2024.

    Copyright: © 2024 Long, Chen, Chen, Ma, Yan, Li, Li, Zhang, Han, Yuan, Li, Lin, Zhao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: XiaoLin Chen, Beijing Tiantan Hospital, Capital Medical University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.