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MINI REVIEW article
Front. Neurol.
Sec. Applied Neuroimaging
Volume 15 - 2024 |
doi: 10.3389/fneur.2024.1465232
This article is part of the Research Topic Neurophotonics in Neurological disorders View all articles
Epilepsy Insights Revealed by Intravital Functional Optical Imaging
Provisionally accepted- 1 School of Medicine, Emory University, Atlanta, United States
- 2 Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, New Jersey, United States
Despite an abundance of pharmacologic and surgical epilepsy treatments, there remain millions of patients suffering from poorly controlled seizures. One approach to closing this treatment gap may be found through a deeper mechanistic understanding of the network alterations that underly this aberrant activity. Functional optical imaging in vertebrate models provides powerful advantages to this end, enabling the spatiotemporal acquisition of individual neuron activity patterns across multiple seizures. This coupled with the advent of genetically encoded indicators, be them for specific ions, neurotransmitters or voltage, grants researchers unparalleled access to the intact nervous system. Here we will review how in vivo functional optical imaging in various vertebrate seizure models has advanced our knowledge of seizure dynamics, principally seizure initiation, propagation and termination.
Keywords: seizure, Multi-photon, GECI, in vivo imaging, neurophotonics
Received: 16 Jul 2024; Accepted: 13 Aug 2024.
Copyright: © 2024 Stern, Dingledine, Gross and Berglund. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Matthew Stern, School of Medicine, Emory University, Atlanta, United States
Ken Berglund, School of Medicine, Emory University, Atlanta, United States
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