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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Autonomic Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1464891

Clinical analysis and case series report on autoimmune glial fibrillary acidic protein astrocytopathy presenting with autonomic dysfunction

Provisionally accepted
Xiaoke Wu Xiaoke Wu 1Jinru Zhang Jinru Zhang 2Huaping Du Huaping Du 1Lan Hu Lan Hu 1Shu Ye Yu Shu Ye Yu 1Hailun Hang Hailun Hang 1Siyu Han Siyu Han 3Yuan Xu Yuan Xu 1*Yanlin Zhang Yanlin Zhang 2*
  • 1 Suzhou Ninth People's Hospital, Suzhou, China
  • 2 Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China
  • 3 Kangda College, Nanjing Medical University, Lian Yungang, China

The final, formatted version of the article will be published soon.

    The incidence of autonomic dysfunction is frequently underestimated and often overlooked in patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A). This study comprehensively analyzes the clinical manifestations, laboratory and imaging findings, and treatment modalities for patients demonstrating GFAP-A involvement in the autonomic nervous system. Conclusion: Bladder dysfunction and gastrointestinal dysfunction are the primary manifestations of autonomic dysfunction in GFAP-A patients, with a subset also experiencing abnormalities in heart rate, blood pressure, and sweating. These additional symptoms have implications for prognosis, necessitating heightened attention from clinicians toward GFAP-A patients.

    Keywords: GFAP-A, autonomic dysfunction, prognosis, Urinary bladder dysfunction, autoimmune glial fibrillary acidic protein astrocytopathy

    Received: 02 Aug 2024; Accepted: 26 Dec 2024.

    Copyright: © 2024 Wu, Zhang, Du, Hu, Ye Yu, Hang, Han, Xu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yuan Xu, Suzhou Ninth People's Hospital, Suzhou, China
    Yanlin Zhang, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.