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BRIEF RESEARCH REPORT article

Front. Neurol.
Sec. Movement Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1463970

Cognitive aspects of motor control deteriorate while off treatment following subthalamic nucleus deep brain stimulation surgery in Parkinson's disease

Provisionally accepted
Miranda J Munoz Miranda J Munoz 1*Rishabh Arora Rishabh Arora 2Yessenia M Rivera Yessenia M Rivera 1Quentin H Drane Quentin H Drane 3Gian D Pal Gian D Pal 4Leo Verhagen Metman Leo Verhagen Metman 1Sepehr B Sani Sepehr B Sani 5Joshua M Rosenow Joshua M Rosenow 1Lisa C Goelz Lisa C Goelz 6Daniel M Corcos Daniel M Corcos 1Fabian J David Fabian J David 1
  • 1 Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States
  • 2 Morsani College of Medicine, USF Health, Tampa, Florida, United States
  • 3 School of Medicine, Creighton University, Omaha, Nebraska, United States
  • 4 Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey, United States
  • 5 Rush University Medical Center, Chicago, Illinois, United States
  • 6 University of Illinois Chicago, Chicago, Illinois, United States

The final, formatted version of the article will be published soon.

    Introduction: The long-term effects of surgery for subthalamic nucleus deep brain stimulation (STN-DBS) on cognitive aspects of motor control for people with Parkinson's disease (PD) are largely unknown. We compared saccade latency and reach reaction time (RT) pre-and postsurgery while participants with PD were off-treatment.Methods: In this preliminary study, we assessed people with PD approximately 1 month presurgery while OFF medication (OFF-MEDS) and about 8 months post-surgery while OFF medication and STN-DBS treatment (OFF-MEDS/OFF-DBS). We examined saccade latency and reach reaction time (RT) performance during a visually-guided reaching task requiring participants to look at and reach towards a visual target.Results: We found that both saccade latency and reach RT significantly increased post-surgery compared to pre-surgery. In addition, there was no significant change in Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part III score. Discussion: We found detrimental post-surgical changes to saccade latency and reach RT. We discuss the potential contributions of long-term tissue changes and withdrawal from STN-DBS on this detrimental cognitive effect.

    Keywords: Parkinson's disease, Deep brain stimulation surgery, saccade, latency, reach, Reaction Time, Cognitive aspects

    Received: 12 Jul 2024; Accepted: 04 Dec 2024.

    Copyright: © 2024 Munoz, Arora, Rivera, Drane, Pal, Verhagen Metman, Sani, Rosenow, Goelz, Corcos and David. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Miranda J Munoz, Feinberg School of Medicine, Northwestern University, Chicago, 60611, Illinois, United States

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.