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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1462414
This article is part of the Research Topic Expanding the Paradigm of the Management of Headaches: Integrated Multidisciplinary Perspectives from Bench to Bedside View all 8 articles

The Role of Digital Device Use on the Risk of Migraine: A univariable and Multivariable Mendelian Randomization study

Provisionally accepted
Zongqing He Zongqing He 1,2Fan Qiu Fan Qiu 1*Jing Yanga Jing Yanga 1,2*Min Zhao Min Zhao 2*
  • 1 Henan University of Chinese Medicine, Zhengzhou, China
  • 2 Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    The pervasive integration of digital devices into daily life has raised concerns about their potential health impacts. This study aimed to explore the causal relationships between digital device use and the risk of migraine using Mendelian randomization (MR).Methods: Genetic data on digital device use and migraines were sourced from large-scale genomewide association studies conducted by UK Biobank, FinnGen Study and the International Headache Genetics Consortium. Univariable MR (UVMR), meta-analysis, and multivariable MR (MVMR) approaches were conducted to explore and verify the causal effects of digital device use (including mobile phone use, computer use, playing computer games, and watching television) on migraine risk. Sensitivity analyses were conducted using Cochran's Q, MR-Egger intercept test, MR pleiotropy residual sum and outlier, MR Radial, MR Steiger and leave-one-out-methods.Results: UVMR analyses revealed that genetically predicted mobile phone use was significantly associated with an increased risk of overall migraine (odds ratio [OR] = 2.39, P = 9.78e-5) and migraine without aura (MO) (OR = 2.25, P = 0.024). Additionally, there were significant positive associations between genetically predicted television watching and the risk of overall migraine (OR = 1.63, P = 2.12e-5) and MO (OR = 2.10, P = 4.98e-5). These results were further supported by the meta-analysis and MVMR analysis. Sensitivity analysis indicated no heterogeneity or pleiotropy.This comprehensive MR study provides preliminary evidence for the causal impact of mobile phone use and television watching on the risk of migraines. Further studies are needed to explore these associations across different populations.

    Keywords: digital device, Migraine, univariable mendelian randomization study, multivariable Mendelian randomization study, casual effect

    Received: 10 Jul 2024; Accepted: 09 Oct 2024.

    Copyright: © 2024 He, Qiu, Yanga and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Fan Qiu, Henan University of Chinese Medicine, Zhengzhou, China
    Jing Yanga, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
    Min Zhao, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China

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