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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Applied Neuroimaging
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1461258
This article is part of the Research Topic Advanced Neuroimaging Techniques for Assessing Cerebrovascular Diseases View all articles

Horizontal analysis and longitudinal cohort study of chronic renal failure correlates and cerebral small vessel disease relationship using Peak width of skeletonized mean diffusivity

Provisionally accepted
Dan Wang Dan Wang Zheng Sun Zheng Sun Yue-hua Li Yue-hua Li *
  • Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China

The final, formatted version of the article will be published soon.

    Background and Purpose: Peak width of skeletonized mean diffusivity (PSMD) is an MRI-based biomarker that may reflect white matter lesions (WML). PSMD is based on skeletonization of MR DTI data and histogram analysis. Both chronic renal failure (CRF) and WML may be affected by multisystemic small-vessel disorder. We aimed to explore the relationship between PSMD and estimated glomerular filtration rate (eGFR).Methods: Fifty followed-up CRF patients matched for age, sex, hypertension and smoking status were enrolled and classified into a progressive group (n=16) and stable group (n=34) based on eGFR levels. Longitudinal and horizontal differences of PSMD were compared between the progressive and stable groups at the initial and follow-up time points. Pearson's correlation was used for correlation of eGFR with PSMD and WML (per Fazekas scale score). ROC curveROC was used to measure the sensitivity of PSMD and WML score to changes of eGFR.Results: At the follow-up time point, PSMD of the progressive group was significantly higher than at the initial time point (P<0.001), and PSMD of the progressive group was significantly higher than stable group (P<0.001). PSMD and eGFR were significantly correlated. AUC curves explored that ΔPSMD (PSMD changes at the follow-up and initial time points) and follow-up PSMD was better for the classification of progressive and stable groups.Conclusions: PSMD has significant correlation with eGFR, PSMD can reveal a close relationship between WML and CRF.

    Keywords: MRI, PSMD, chronic renal failure, White matter lesion, cerebrovascular

    Received: 08 Jul 2024; Accepted: 27 Aug 2024.

    Copyright: © 2024 Wang, Sun and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yue-hua Li, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China

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