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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Movement Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1459576
This article is part of the Research Topic Clinical and Neurophysiological Features of Progressive Supranuclear Palsy and Other Parkinsonism Syndromes View all articles

GRIN2B Polymorphism Is Associated with Parkinson's Disease Risk, Age at Onset, and Progression in southern China

Provisionally accepted
Bei Zhang Bei Zhang 1*Can Cui Can Cui 1Hongxia Li Hongxia Li 1*Yiwen Bao Yiwen Bao 1*Yingying Han Yingying Han 1*Hongxiang Yu Hongxiang Yu 1Huan Song Huan Song 2*
  • 1 Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
  • 2 Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

The final, formatted version of the article will be published soon.

    The role of N-methyl-D-aspartate receptor 2B (GRIN2B) single nucleotide polymorphisms (SNPs) in influencing the risk and progression of Parkinson's disease (PD) is still unclear. This study is designed to assess the impact of GRIN2B genotype status in PD susceptibility and symptom progression.We enrolled 165 individuals with sporadic PD and 154 healthy controls, all with comprehensive clinical data at the start and during follow-up. We used chi-square (χ 2 ) analysis to compare the allele and genotype frequency distributions between the patient and control groups.Linear mixed-effect models were employed to investigate the link between GRIN2B genotype and the progression of motor and cognitive symptoms.The prevalence of the GG+GT genotype and G allele was higher in patients compared to controls (P = 0.032 and P = 0.001, respectively). Subgroup analysis revealed that the GG+GT genotype and G allele were significantly more frequent in late-onset PD (LOPD) patients than in early-onset PD patients (P = 0.014 and P = 0.035, respectively). Notably, individuals with the GG+GT genotype exhibited an estimated annual progression rate of 6.10 points on the UPDRS motor scale, significantly faster than that of TT genotype carriers. Furthermore, GG+GT carriers showed a pronouncedly rapid progression in rigidity. Additionally, GG+GT carriers demonstrated significantly faster progression rates in rigidity (1.83 points/year) and axial impairment (1.2 points/year) compared to TT carriers. Notably, GG genotype carrier exhibit a more rapid decline in recall function.The GRIN2B rs219882 G allele is associated with increased PD susceptibility, particularly in LOPD. Carriers of the GG+GT genotype exhibit a more rapid motor symptom progression, with a pronounced impact on rigidity and axial impairment.

    Keywords: Grin2b, Parkinson's disease, Motor progression, LOPD, rigidity, Axial impairment

    Received: 04 Jul 2024; Accepted: 19 Nov 2024.

    Copyright: © 2024 Zhang, Cui, Li, Bao, Han, Yu and Song. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bei Zhang, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Hongxia Li, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Yiwen Bao, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Yingying Han, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China
    Huan Song, Huashan Hospital, Fudan University, Shanghai, Shanghai Municipality, China

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