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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Applied Neuroimaging
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1459356
This article is part of the Research Topic Advancements in the Management of Cardio-Renal Syndrome: Pioneering Treatments and Therapeutic Breakthroughs View all 5 articles

Choroid plexus enlargement in patients with end-stage renal disease: implications for glymphatic system dysfunction

Provisionally accepted
Sihyung Park Sihyung Park Bong Soo Park Bong Soo Park Ho-Joon Lee Ho-Joon Lee Chang Min Heo Chang Min Heo Dong Ah Lee Dong Ah Lee Kang Min Park Kang Min Park *
  • Inje University Haeundae Paik Hospital, Busan, Republic of Korea

The final, formatted version of the article will be published soon.

    The choroid plexus plays a role in eliminating detrimental metabolites from the brain as an integral component of the glymphatic system. This study aimed to investigate alterations in choroid plexus volume in patients with end-stage renal disease (ESRD) compared with healthy controls.We enrolled 40 patients with ESRD and 42 healthy controls. They underwent brain magnetic resonance imaging (MRI), specifically using three dimensional T1-weighted imaging. We analyzed choroid plexus volumes and compared them between patients with ESRD and healthy controls. The diffusion tensor image analysis along the perivascular space (DTI-ALPS) index was calculated. We compared the DTI-ALPS index between the ESRD patients and healthy controls. Additionally, we evaluated the association between choroid plexus volume and neuropsychological tests results in patients with ESRD.Results: There were significant differences in choroid plexus volumes between patients with ESRD and healthy controls. The choroid plexus volumes in patients with ESRD were higher than those in healthy controls (1.392 vs. 1.138 %, p<0.001). The DTI-ALPS index in patients with ESRD was lower than that in healthy controls (1.470±0.239 vs. 1.641±0.266, p=0.005). There were no differences in choroid plexus volumes between patients with ESRD, regardless of the presence of cognitive impairment. However, among the neuropsychological tests, the scores for word-list recognition in verbal memory were negatively correlated with the choroid plexus volume (r = -0.428, p = 0.006).We demonstrated a significant enlargement of the choroid plexus volume in patients with ESRD compared to healthy controls. This finding suggests that patients with ESRD have glymphatic system dysfunction, which may be related to cognitive impairment.

    Keywords: Glymphatic system, Choroid Plexus, Cognition, ESRD, MRI

    Received: 04 Jul 2024; Accepted: 02 Oct 2024.

    Copyright: © 2024 Park, Park, Lee, Heo, Lee and Park. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Kang Min Park, Inje University Haeundae Paik Hospital, Busan, Republic of Korea

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