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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neurological Biomarkers
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1456884

Association between platelet-to-red cell distribution width ratio and allcause mortality in critically ill patients with non-traumatic cerebral hemorrhage: a retrospective cohort study

Provisionally accepted
Rongrong Lu Rongrong Lu 1Changcai Wu Changcai Wu 2*
  • 1 Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China
  • 2 First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, China

The final, formatted version of the article will be published soon.

    The purpose of this study was to investigate the relationship between platelet-to-red cell distribution width ratio (PRR) and all-cause mortality in critically ill patients with non-traumatic cerebral hemorrhage (NCH).The Medical Information Mart for Intensive Care (MIMIC-IV) database was used to identify patients with NCH who needed to be admitted to intensive care unit (ICU). The outcomes of the study included both ICU and in-hospital mortality. Restricted cubic splines and Cox proportional hazards regression analysis were used to clarify the relationship between PRR and clinical outcomes in critically ill patients with NCH.Results A total of 3094 patients (54.0% male) were included in the study, with in-hospital mortality and ICU mortality rates of 16.5% and 11.8%, respectively. A substantial correlation was found by multivariate Cox proportional hazards analysis between increased PRR and a lower risk of in-hospital and ICU mortality.Following adjustment for confounding factors, patients with elevated PRR exhibited a significantly decreased risk of in-hospital death (HR, 0.98; 95% CI, 0.96-0.99; P = 0.006) and ICU death (HR, 0.98; 95% CI, 0.96-0.99; P = 0.027). As PRR increased, restrictive cubic splines showed a progressive decrease in the probability of all-cause mortality. Stratified analyses indicated a consistent association between PRR and both in-hospital and ICU mortality.Among critically ill patients with NCH, elevated PRR was substantially correlated with the increased probability of all-cause mortality in both the ICU and hospital. According to this research, PRR might be a valuable indicator for identifying NCH patients at risk of all-cause mortality.

    Keywords: Platelets to red cell distribution width ratio, Nontraumatic cerebral hemorrhage, MIMIC-IV database, All-cause mortality, critically ill patients

    Received: 29 Jul 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Lu and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Changcai Wu, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, Zhejiang Province, China

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