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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1454056
This article is part of the Research Topic Clinical Therapy of Brain Tumors View all 17 articles

Polymorphic Low-Grade Neuroepithelial Tumors of the young: Disease Characteristics and Treatment Decisions from the Epilepsy Surgery Perspective

Provisionally accepted
Guilu He Guilu He 1Qiang Guo Qiang Guo 2*Hongping Tan Hongping Tan 2*Shaochun Li Shaochun Li 2*limin Zhang limin Zhang 2*Qiao Li Qiao Li 2*
  • 1 Department of Neurosurgery, Guangdong Sanjiu Brain Hospital, Department of Neurosurgery, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province, China
  • 2 Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, China

The final, formatted version of the article will be published soon.

    The Polymorphic Low-Grade Neuroepithelial Tumor of the Young (PLNTY) is a rare, epilepsy-associated brain tumor that has been increasingly recognized but is not well understood due to the scarcity of clinical reports. Our study reviews the clinical characteristics and treatment outcomes of 14 patients with PLNTY to enhance the understanding of this condition from an epilepsy surgery perspective.We performed a retrospective analysis of 14 PLNTY cases at our hospital. A literature review on prior studies was also conducted.Our study included 8 males and 6 females, all presenting with epilepsy. Despite anti-seizure medication, 92.3% of patients continued to have seizures, with 58.3% diagnosed as having drug-resistant epilepsy. Neuroimaging revealed that 64.3% of the lesions were in the temporal lobe, with 75.0% showing calcification on CT, 71.4% exhibiting mixed signals on T2-weighted images, and 92.7% showing tumor enhancement. The transmantle sign was noted in 57.1% of T2 FLAIR sequences. EEGs indicated abnormal activity in 69.2% of patients, with 30.7% showing bilateral discharges. SEEG in two patients confirmed the tumor's epileptogenicity. A 78.6% total resection rate was achieved, with a 90.0% postoperative seizure-free rate and an 85.7% excellent Engel grade 1 rate. No instances co-occurring with focal cortical dysplasia (FCD) were observed.PLNTY is characterized by unique neuroimaging features and a strong association with epilepsy. SEEG is pivotal for cases with unclear lateralization, aiding in identifying the link between the tumor and seizures. Following established epilepsy surgery protocols for brain tumor management, Early intervention and extended resection can improve the rate of postoperative seizure freedom.

    Keywords: PLNTY, Stereoelectroencephalography (SEEG), Epilepsy, Neuroepithelial tumors, Treatment

    Received: 24 Jun 2024; Accepted: 28 Oct 2024.

    Copyright: © 2024 He, Guo, Tan, Li, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Qiang Guo, Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, 510510, China
    Hongping Tan, Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, 510510, China
    Shaochun Li, Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, 510510, China
    limin Zhang, Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, 510510, China
    Qiao Li, Department of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, 510510, China

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