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SYSTEMATIC REVIEW article

Front. Neurol.
Sec. Neuro-Otology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1453055

Efficacy of hyperbaric oxygen therapy in treating sudden sensorineural hearing loss: an umbrella review

Provisionally accepted
Xinghong Liu Xinghong Liu 1Xianpeng Xu Xianpeng Xu 1Qiulian Lei Qiulian Lei 1Xiaohua Jin Xiaohua Jin 1Xinxing Deng Xinxing Deng 1Hui Xie Hui Xie 2*
  • 1 Chengdu University of Traditional Chinese Medicine, Chengdu, China
  • 2 Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China

The final, formatted version of the article will be published soon.

    Intr oduction:Our objective was to explore the efficacy of hyperbaric oxygen in the treatment of sudden sensorineural hearing loss by conducting an umbrella review of all existing evidence. Methods:We conducted an umbrella review, searching for related articles in the PubMed, Web of Science, Embase, and Scopus databases. The search period covered from the inception of each database until April 2024.We extracted authors, country of publication, time of publication, number of included studies and participants, interventions, summary of results, p-values, I², relative risk (95% CI), and outcome measures. The methodological quality, evidence quality, and overlap rate of the included articles were assessed using AMSTAR 2, GRADE, and OVErviews (GROOVE).Results:Methodological quality was assessed using AMSTAR 2. Of the 9 included articles, 2 were assessed as "high", 3 as "moderate", 2 as "low", and the remaining 2 as "very low". The quality of evidence was assessed using the GRADE system. It was found that the quality of evidence in most of the studies was unsatisfactory. It was found that there was a slight overlap among the included articles. 6 studies reported positive results (OR 1.37; 95% CI, 1.17-1.61; P=0.04), with high heterogeneity observed (I2=63%). Egger's test indicated bias (P=0.000101). 3 studies reported negative results (MD 1.49; 95% CI, -0.32-3.29; P=0.43; I2=0%), with no significant bias detected (P=0.106) according to Egger's test.Conclusion:HBO therapy is shown to be an effective treatment for SSNHL with fewer side effects. However, the methodological quality and evidence of the systematic reviews and meta-analysis included in this study were generally low. Therefore, more high-quality, large-scale, multi-center randomized controlled trials are needed in the future to verify the efficacy of HBO therapy for SSNHL.

    Keywords: Sudden sensorineural hearing loss, hyperbaric oxygen, efficacy, Systematic review, Meta-analysis

    Received: 25 Jun 2024; Accepted: 24 Jul 2024.

    Copyright: © 2024 Liu, Xu, Lei, Jin, Deng and Xie. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Hui Xie, Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.