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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1448428

Sex-differential effect of waist circumference on newonset cerebral infarction: A nationwide cohort study

Provisionally accepted
Sang Min Lee Sang Min Lee 1Minha Hong Minha Hong 2Jae-Hong Ryoo Jae-Hong Ryoo 3*
  • 1 Department of Psychiatry Kyung Hee University Hospital, Seoul, Republic of Korea
  • 2 Department of Psychiatry Myongji Hospital, Hanyang University College of Medicine, Goyang, Gyeonggi, Republic of Korea
  • 3 Kyung Hee University Hospital, Dongdaemun, Seoul, Republic of Korea

The final, formatted version of the article will be published soon.

    Excessive abdominal adiposity represents a cardiovascular disease risk factor.Waist circumference (WC) reflects abdominal adiposity and is known as an easyto-measure indicator of obesity. This study aimed to evaluate the relationship between WC level and the development of cerebral infarction in Koreans. 209,442 Koreans were included among the general population registered in the National Health Information Database. Depending on the degree of WC, the possibility of cerebral infarction was tracked for 4.37 person-years. Identification of patients with cerebral infarction was confirmed through the diagnostic code ICD I63 of inpatient or outpatient. Participants' data were analyzed by sex. The hazard ratios (HRs) and confidence interval (CI) for cerebral infarction were calculated using the Cox proportional hazards model. Between 2009 and 2013, 2,403 cases (1.15%) of cerebral infarction occurred during the follow-up period of 915,223.6 person-years. The HRs (95% CI) for incident cerebral infarction in men was adjusted for multiple covariates, and comparison of WC levels second,third, and fourth quartile with the first quartile showed 1.10 (0.94-1.28), 1.11 (0.95-1.30), and 1.24 (1.07-1.45), respectively (P for trend 0.045). This association was not significant in women (P for trend 0.619). The severity of WC levels in men is significantly associated with the risk of developing cerebral infarction in Koreans. This finding indicates that other measurements for excessive adipose visceral tissue, except abdominal circumference, need to be taken into account to identify the risk of cerebral infarction in women.

    Keywords: Waist Circumference, Cerebral Infarction, cohort study, Stroke, Gender difference

    Received: 13 Jun 2024; Accepted: 27 Sep 2024.

    Copyright: © 2024 Lee, Hong and Ryoo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jae-Hong Ryoo, Kyung Hee University Hospital, Dongdaemun, 02447, Seoul, Republic of Korea

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