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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuroepidemiology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1448377

Global burden of multiple sclerosis and its attributable risk factorin 204 countries and territories, 1990-2019

Provisionally accepted
Saeid Safiri Saeid Safiri 1*Amir Ghaffari Amir Ghaffari 2Seyed Ehsan Mousavi Seyed Ehsan Mousavi 1Seyed Aria Nejadghaderi Seyed Aria Nejadghaderi 3Mark J. Sullman Mark J. Sullman 4Ali-Asghar Kolahi Ali-Asghar Kolahi 5
  • 1 Tabriz University of Medical Sciences, Tabriz, Iran
  • 2 Iran University of Medical Sciences, Tehran, Tehran, Iran
  • 3 Kerman University of Medical Sciences, Kerman, Kerman, Iran
  • 4 University of Nicosia, Nicosia, Nicosia, Cyprus
  • 5 Shahid Beheshti University of Medical Sciences, Tehran, Tehran, Iran

The final, formatted version of the article will be published soon.

    Background: Multiple sclerosis (MS) is a progressively and debilitating disease disorder that has shown seen a notable rise inan increasing prevalence in recent years. We aimed to reportThis study examines the burden of MS from 1990 to 2019, providing a detailed analysis by age, gendersex, age, sex and sociodemographic index (SDI) in across 204 countries and territories.Methods: Publicly accessible dData on the prevalence, death and disability-adjusted life years (DALYs) due attributable to MS were accessed obtained from the publically available Global Burden of Disease 2019 project. The estimates were are reportedreported as numbers, percentages, and age-standardised rates per 100,000, along accompanied bywith 95% uncertainty intervals.In 2019, MS accounted accounted for 1.8 million prevalent cases, 22.4 thousand deaths and 1.2 million DALYs worldwide. There were Ssignificant decreases declines were observed in the global age-standardised prevalence, death mortality and DALY rates of MS over the period 1990-2019 from 1990 to 2019. In 2019, females exhibited a higher the global point prevalence and a greater total number of prevalent MS cases were than higher in females than males across all age groups. At the regional level, we observed a non-linear association relationship was observed between the age-standardised DALY rate of MS and the SDI.Although the global age-standardized DALY rate of MS decreased between 1990 and 2019, MS continues to account for a considerable portion number of DALYs and prevalent cases and DALYs. Integrating MS and its associated risk factors into healthcare planning is vital, particularly especially in regions areas with high levels of socioeconomic development.

    Keywords: Multiple Sclerosis, death, Prevalence, Disability adjusted life years, global

    Received: 13 Jun 2024; Accepted: 07 Oct 2024.

    Copyright: © 2024 Safiri, Ghaffari, Mousavi, Nejadghaderi, Sullman and Kolahi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Saeid Safiri, Tabriz University of Medical Sciences, Tabriz, Iran

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.