Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1447461

Assessment of Rab geranylgeranyltransferase subunit beta in Amyotrophic lateral sclerosis

Provisionally accepted
Jing Yang Jing Yang 1,2,3*Mei Tian Mei Tian 1Lei Zhang Lei Zhang 1Cheng Xin Cheng Xin 1Jia Huo Jia Huo 1Qi Liu Qi Liu 1Hui Dong Hui Dong 1Rui Li Rui Li 1Yaling Liu Yaling Liu 1
  • 1 Second Hospital of Hebei Medical University, Shijiazhuang, China
  • 2 Key Laboratory of Neurology and Vascular Biology, Ministry of Education, Shijiazhuang, Hebei, China
  • 3 Hebei Provincial Center for Clinical Laboratory, Shijiazhuang, Hebei Province, China

The final, formatted version of the article will be published soon.

    Introduction: Geranylgeranyltransferase Subunit Beta (RABGGTB) was expressed at higher levels in patients with Amyotrophic lateral sclerosis (ALS) compared with healthy controls. This study aims to observe the expression of RABGGTB in different cells from patients with ALS and different diseases.In this case-control study, we collected peripheral blood from patients with ALS and healthy controls, and compared the expression of RABGGTB in natural killer cells (NK), T cells and B cells between patients with ALS and healthy controls by flow cytometry. And compared the expression of RABGGTB in monocytes and monocyte-derived macrophages from patients with ALS, Parkinson's disease (PD), acute cerebrovascular disease (ACVD) and healthy controls by flow cytometry and immunofluorescence. Then flow cytometry was used to detect the expression of RABGGTB in monocytes from SOD1G93A mice and WT mice.The expression of RABGGTB was not significantly changed in NK cells, cytotoxic T cells (CTL), helper T cells (Th), regulatory T cells (Treg) and B cells from patients with ALS compared to healthy controls. And the expression of RABGGTB in monocytes and monocyte-derived macrophages was higher in the ALS group than in the PD, ACVD and control group. The expression of RABGGTB was significantly higher in monocytes of SOD1G93A mice compared to WT mice.These findings suggest that RABGGTB expression was increased in monocytes and monocyte-derived macrophages from patients with ALS, not in NK, CTL, Th, Treg and B cells. Future studies are needed to find the clinical implication of RABGGTB in ALS.

    Keywords: RABGGTB, mononuclear cells-macrophages, ALS, PD, ACVD

    Received: 11 Jun 2024; Accepted: 01 Aug 2024.

    Copyright: © 2024 Yang, Tian, Zhang, Xin, Huo, Liu, Dong, Li and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Jing Yang, Second Hospital of Hebei Medical University, Shijiazhuang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.