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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1446472
This article is part of the Research Topic Neuroinfection-Related Immunity and Inflammation View all 6 articles

Causal Relationship between Immune Cells and Guillain-Barre Syndrome: a Mendelian Randomisation Study

Provisionally accepted
Huaiquan LIU Huaiquan LIU *Shuoshuo Shao Shuoshuo Shao Bo Chen Bo Chen Shili Yang Shili Yang Xinyan Zhang Xinyan Zhang
  • Guizhou University of Traditional Chinese Medicine, Guiyang, China

The final, formatted version of the article will be published soon.

    Abstract: Objective: The aim of this study was to investigate the causal effect of immune cell phenotype on GBS using two-sample Mendelian randomisation (MR) approach. Methods: This study used MR to investigate the causal relationship between 731 immune cell phenotypes and GBS. We used Inverse variance weighted, Weighted median, MR Egger, Simple mode, Weighted mode for MR analysis. We also used the Cochran Q test, MR-Egger intercept test, IVW regression and MR-PRESSO, leave-one-out analysis to assess the presence of horizontal pleiotropy, heterogeneity and stability respectively. Results: Our study revealed a causal relationship between 33 immune cell phenotypes and GBS. Twenty immunophenotypes were observed to be associated with GBS as risk factors. For example, CD20 on IgD+ CD38dim in the B cell group (OR=1.313, 95%CI：1.042-1.654，P =0.021), CD3 on CD4 Treg in Treg cell group (OR=1.395，95%CI：1.069-1.819，P =0.014), CD3 on TD CD8br in Maturation stages of T cell group (OR=1.486，95%CI：1.025-2.154，P =0.037), CD16 on CD14+ CD16+ monocyte in Monocyte group (OR=1.285，95%CI：1.018-1.621，P =0.035), CD33dim HLA DR+ CD11b+ %CD33dim HLA DR+ in Myeloid cell group (OR=1.262，95%CI：1.020-1.561，P =0.032), HLA DR+ NK AC in TBNK cell group (OR=1.568，95%CI：1.100-2.237，P =0.013). Thirteen immune phenotypes are associated with GBS as protective factors. For example, CD19 on PB/PC in the B cell group (OR=0.577，95%CI：0.370-0.902，P =0.016), CD4 Treg AC in Treg cell group (OR=0.727，95%CI：0.538-0.983，P =0.038), CD11c+ monocyte %monocyte in cDC group (OR=0.704，95%CI：0.514-0.966，P =0.030), CX3CR1 on CD14+ CD16- monocyte in Monocyte group (OR=0.717，95%CI：0.548-0.9939，P =0.016), Mo MDSC AC in Myeloid cell group (OR=0.763，95%CI：0.619-0.939，P =0.011), CD45 on granulocyte in TBNK group (OR=0.621，95%CI：0.391-0.984，P =0.042). Conclusions: The findings suggest that certain specific immune cell phenotypes, particularly B cell and Treg cell subpopulations, are causally associated with GBS, providing potential targets for the clinical treatment of GBS.

    Keywords: Mendelian randomization, Genome-Wide Association Study, immune cells, Guillain-Barré syndrome, causal relationship

    Received: 25 Jun 2024; Accepted: 30 Oct 2024.

    Copyright: © 2024 LIU, Shao, Chen, Yang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Huaiquan LIU, Guizhou University of Traditional Chinese Medicine, Guiyang, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.