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SYSTEMATIC REVIEW article

Front. Neurol.
Sec. Neuromuscular Disorders and Peripheral Neuropathies
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1442841

Acupuncture in the treatment of chemotherapy-induced peripheral neuropathy: a meta-analysis and data mining

Provisionally accepted
Li Limeng Li Limeng Yingxue Huang Yingxue Huang *An chengfei An chengfei *Jing Ning Jing Ning *Chuhan Xu Chuhan Xu *Wang Xiaoyu Wang Xiaoyu Huanan Li Huanan Li Tao Tan Tao Tan *
  • National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China

The final, formatted version of the article will be published soon.

    The efficacy and acupoint selection of acupuncture in treating chemotherapy-induced peripheral neuropathy (CIPN) remain controversial. This study aims to explore the specific efficacy and acupoint selection of acupuncture in treating CIPN through a meta-analysis and data mining.Searching for clinical trials on acupuncture treatment for CIPN in 8 databases, evaluating its efficacy and safety through a meta-analysis, and exploring its acupoint selection through data mining.The meta-analysis included 21 studies and 2121 patients, showing that compared with the control group, the acupuncture group could significantly improve neuropathic pain intensity (SMD= -0.66, 95% CI [-1.07, -0.25], P =0.002), significantly reduce the NCI-CTCAE (SMD = -0.53, 95% CI [-0.75,-0.31], P < 0.001), significantly reduce the FACT-NXT score (SMD= 0.26, 95% CI [0.03,0.49], P < 0.05), significantly increase the motor conduction velocities (MCV) of median nerve (MD= 2.38, 95% CI [2.10, 2.67], P < 0.001), the sensory conduction velocities (SCV) of the median nerve (MD= 0.56, 95 %CI [-1.45, 2.57], P =0.58), the SCV of the tibial nerve (MD = 1.78, 95% CI [0.50, 3.05], P < 0.01), and the SCV of sural nerves (MD = 4.60, 95% CI [0.17, 9.02], P < 0.05), as well as improving the quality of life score (MD =7.35, 95% CI [1.53, 13.18], P =0.01). Data mining showed that the core acupoints for acupuncture treatment of CIPN were LI4, ST36, LI11, LR3, and SP6.Acupuncture can improve the neuropathic pain intensity, the intensity of the CIPN, MCV of the median nerve, SCV of the tibial nerve and peroneal nerve, quality of life, and has good safety in CIPN patients. LI4 (Hegu), ST36 (Zusanli), LI11 (Quchi), LR3 (Taichong), and SP6 (Sanyinjiao) are the core acupuncture points for treating CIPN, and this protocol has the potential to become a supplementary treatment for CIPN.

    Keywords: Acupuncture, Systematic review, Chemotherapy-induced peripheral neuropathy, Data Mining, complementary and alternative therapies

    Received: 03 Jun 2024; Accepted: 30 Sep 2024.

    Copyright: © 2024 Limeng, Huang, chengfei, Ning, Xu, Xiaoyu, Li and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yingxue Huang, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
    An chengfei, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
    Jing Ning, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
    Chuhan Xu, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China
    Tao Tan, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion Tianjin, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Nankai District, China

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