Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1440995

Inflammo-immune perspective on the association of eight migraine risk factors with migraine: A multi-omics Mendelian randomization study

Provisionally accepted
Jiaxi Zhao Jiaxi Zhao 1*Rong Chen Rong Chen 2Mengqi Luo Mengqi Luo 3Hongping Gong Hongping Gong 1Kaixin Li Kaixin Li 4,5Qian Zhao Qian Zhao 1*
  • 1 International Medical Center Ward General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China
  • 2 Department of Rehabilitation Medicine, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
  • 3 Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China
  • 4 Metro South Clinical Tuberculosis Service, Princess Alexandra Hospital, Brisbane, Australia
  • 5 Centre for Health Services Research, Faculty of Medicine, The University of Queensland, Woolloongabba, Australia

The final, formatted version of the article will be published soon.

    Background: Migraine risk factors are associated with migraine susceptibility, yet their mechanisms are unclear. Evidence suggests a role for inflammatory proteins and immune cells in migraine pathogenesis. This study aimed to examine the inflammo-immune association between eight migraine risk factors and the disorder. Methods: This study utilized inverse variance weighted (IVW) method and colocalization analysis to explore potential causal relationships between eight migraine risk factors, migraine, 731 immune cells, and 91 circulating inflammatory proteins. Mediation Mendelian randomization (MR) was further used to confirm the mediating role of circulating inflammatory proteins and immune cells between the eight migraine risk factors and migraine. Results: Migraine risk factors are linked to 276 immune cells and inflammatory proteins, with cigarettes smoked per day strongly co-localized with CD33-HLA DR+ cells. Despite no colocalization, 23 immune cells /inflammatory proteins relate to migraine. Depression, all anxiety disorders, and sleep apnea are correlated with migraine, and all anxiety disorders are supported by strong co-localization evidence. However, the mediating effect of inflammatory proteins and immune cells between eight migraine risk factors and migraine has not been confirmed.We elucidate the potential causal relationships between eight migraine risk factors, migraine, immune cells, and inflammatory proteins, enhancing our understanding of the molecular etiology of migraine pathogenesis from an inflammatory-immune perspective.

    Keywords: Inflammatory proteins, immune cells, multiomics, Migraine, Mendelian randomization

    Received: 31 May 2024; Accepted: 26 Jul 2024.

    Copyright: © 2024 Zhao, Chen, Luo, Gong, Li and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaxi Zhao, International Medical Center Ward General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China
    Qian Zhao, International Medical Center Ward General Practice Medical Center, West China Hospital, Sichuan University, Chengdu, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.