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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Stroke
Volume 15 - 2024 |
doi: 10.3389/fneur.2024.1438728
Admission albumin-globulin ratio associated with delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage
Provisionally accepted
Xiumei Guo
1*
Xiong Yu
2
Wen Gao
1*
Xinyue Huang
2*
Hanlin Zheng
2*
Yinfeng Xiao
3
Qiaoling Liu
3*
Zhigang Pan
2*
Chunhui Chen
2*
Weipeng Hu
2*
Lingxing Wang
1*
Feng Zheng
2*- 1 neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- 2 neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
- 3 Clinical Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Despite the widespread use in ischemic stroke, cancer, and malnutrition, the predictive ability of serum albumin to globulin ratio (A/G) among patients suffering from aneurysmal subarachnoid hemorrhage (aSAH) remains unknown. This study aimed to determine if serum A/G ratio is associated with the occurrence of delayed cerebral ischemia (DCI) after aSAH. Medical records of 363 patients with aSAH from August 2017 to August 2022 were reviewed, with DCI observed in 87 (23.97%) cases. Laboratory data for albumin and globulin levels were obtained within 24 h after admission. The serum A/G ratio was classified depending on the presence of DCI. The predictors of DCI were determined using logistic regression. Furthermore, receiver operating characteristic (ROC) curves were used to calculate the association between serum A/G levels and the incidence of DCI. Serum A/G, non-surgical treatment, lactate dehydrogenase (LDH), phosphorous, and plasma fibrinogen were associated with the occurrence of DCI. ROC curves confirmed the predictive potential of serum A/G, non-surgical treatment, LDH, phosphorus, and plasma fibrinogen levels for DCI in patients with aSAH. In conclusion, serum A/G levels are correlated with DCI in individuals with aSAH, and high serum A/G levels on admission may be associated with the occurrence of DCI.
Keywords: aneurysmal subarachnoid Hemorrhage, delayed cerebral ischemia, serum albumin to globulin ratio, Lactate dehydrogenase, phosphorous, and plasma fibrinogen
Received: 26 May 2024; Accepted: 08 Oct 2024.
Copyright: © 2024 Guo, Yu, Gao, Huang, Zheng, Xiao, Liu, Pan, Chen, Hu, Wang and Zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xiumei Guo, neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Wen Gao, neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Xinyue Huang, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Hanlin Zheng, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Qiaoling Liu, Clinical Laboratory, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Zhigang Pan, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Chunhui Chen, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Weipeng Hu, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Lingxing Wang, neurology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
Feng Zheng, neurosurgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China
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