Skip to main content

BRIEF RESEARCH REPORT article

Front. Neurol.
Sec. Cognitive and Behavioral Neurology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1436010
This article is part of the Research Topic Recent advances in research on cognitive frailty and related conditions View all 7 articles

Cognitive Function in Dyslipidemia Patients: Exploring the Impact of Statins

Provisionally accepted
Wenxiao Wang Wenxiao Wang 1,2Xin Li Xin Li 1*
  • 1 Beijing Normal University, Beijing, China
  • 2 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, China

The final, formatted version of the article will be published soon.

    Background: Evidence regarding the relationship between the use of statins and cognitive outcomes presents varying findings. This study aims to analyze the relationship between sustained statin use and cognitive performance in dyslipidemia patients. Methods: This study presents findings from the Beijing Ageing Brain Rejuvenation Initiative (BABRI) study, in which a cohort of community-dwelling dyslipidemia patients (Entire sample, N=1062, aged 50-86) was recruited.Participants were divided into two groups based on their sustained use statins (Statins group, N=677) or not use any lipid-lowering agents (Untreated group, N=385). Furthermore, the entire sample was stratified by age into the middle-aged sample (N=451) and the older people sample (N=611), following a similar categorization based on statin application. ANCOVA was used to evaluate the relationship between sustained statin use and cognitive function. Results: Overall, in the total sample, the statins group demonstrated better cognition in overall cognition, memory, visuospatial ability, attention, executive function, and language domains compared to the untreated group.Moreover, the statins group only showed better performance in attention among the middle-aged sample. In the older people sample, statins group exhibited superior cognitive performance across various cognitive domains compared to untreated group. Conclusion: Among dyslipidemia patients in Beijing community, sustained statin users exhibited superior cognitive function across all domains compared to untreated individuals, with particularly noticeable improvements among those aged 65 and above. These findings underscore the protective effect of statins on cognitive function in dyslipidemia patients, highlighting significant benefits for the older people population.

    Keywords: Cognitive Function, Statins, Dyslipidemia, Aging cohorts, Lipid-lowering agents

    Received: 21 May 2024; Accepted: 03 Sep 2024.

    Copyright: © 2024 Wang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Xin Li, Beijing Normal University, Beijing, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.