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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1432966

Bidirectional two-sample Mendelian randomization analysis identifies causal associations between Migraine and 5 Psychiatric disorders

Provisionally accepted
Wen-Wei Li Wen-Wei Li *Zhi-kun Qiu Zhi-kun Qiu Jia-Xin Zhang Jia-Xin Zhang Ya-Qing Chen Ya-Qing Chen Sha Lai Sha Lai Zhi-kun Qiu Zhi-kun Qiu
  • The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

The final, formatted version of the article will be published soon.

    The question of whether a correlation exists between migraine and 5 psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), anorexia nervosa (AN), bipolar disorder (BIP), and schizophrenia (SCZ), remains a matter of controversy. Hence, this research aims to investigate whether there is a possible association between migraine and 5 psychiatric disorders.We performed a bidirectional 2-sample Mendelian randomization (MR) analysis to assess the causality between migraine and 5 psychiatric disorders. Genetic associations of PTSD, MDD, AN, BIP, and SCZ were obtained from the Psychiatric Genomics Consortium (PGC) database and genetic associations of migraine with aura and migraine without aura were obtained from the FinnGen dataset. We used the inverse-variance weighted (IVW), weighted median, weighted mode, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), and MR Egger regression methods to evaluate the association of genetically predicted exposure with the risk of outcome.Results: MR demonstrated that MDD was associated with a high risk of migraine without aura (OR= 1.930578, 95% confidence interview (CI): 1.224510, 3.043550, p<0.05), but BIP was related to a low risk of migraine without aura (OR= 0.758650, 95%CI: 0.639601, 0.899858, p<0.05). According to the results of reverse MR, migraine with aura was associated with a high risk of BIP (OR= 1.019100, 95%CI: 1.002538, 1.035935, p<0.05), and migraine without aura was associated with an increased risk of AN (OR= 1.055634, 95%CI: 1.023859, 1.088394, p<0.05).Our results provide evidence of the potential causal association between migraine and some psychiatric disorders. It may contribute to the prevention of migraine and some psychiatric disorders.

    Keywords: Migraine, posttraumatic stress disorder, Major Depressive Disorder, Anorexia Nervosa, Bipolar Disorder, Schizophrenia, Mendelian randomization

    Received: 15 May 2024; Accepted: 22 Jul 2024.

    Copyright: © 2024 Li, Qiu, Zhang, Chen, Lai and Qiu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Wen-Wei Li, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.