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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neurological Biomarkers
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1432401

Association between Systemic Immune-Inflammation Index and Serum Neurofilament Light Chain: A Population-Based Study from the NHANES (2013-2014)

Provisionally accepted
Xinyu Liu Xinyu Liu Yue Yang Yue Yang Qiutong Lu Qiutong Lu Jianshu Yang Jianshu Yang Jing Yuan Jing Yuan Jun Hu Jun Hu Yue Tu Yue Tu *
  • Nanjing University of Chinese Medicine, Nanjing, China

The final, formatted version of the article will be published soon.

    The systemic immune-inflammation index (SII) is a novel inflammatory marker used to assess the immune-inflammatory status of the human body. The systemic immune inflammation has an interplay and mutual relationship with neurological disorders. Serum neurofilament light chain (sNfL) is widely regarded as a potential biomarker for various neurological diseases. The study aimed to examine the association between SII and sNfL.Methods: This cross-sectional investigation was conducted in a population with complete data on SII and sNfL from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). The SII was calculated by dividing the product of platelet count and neutrophil count by the lymphocyte count. Multivariate linear regression models and smooth curves were used to explore the linear connection between SII and sNfL. Sensitivity analyses, interaction tests, and diabetes subgroup smoothing curve fitting were also performed.Results: A total of 2,025 participants were included in our present research. SII showed a significant positive association with the natural logarithm-transformed sNfL (ln-sNfL) in crude model [0.17(0.07, 0.28)], partially adjusted model [0.13(0.03, 0.22)], and fully adjusted model [0.12(0.02, 0.22)]. In all participants, the positive association between SII and ln-sNfL served as a linear relationship, as indicated by a smooth curve. Interaction tests showed that age, gender, BMI, hypertension, and diabetes did not have a significant impact on this positive association (p for interaction > 0.05). The subgroup analysis of diabetes was conducted using smooth curve fitting. It was found that compared to the group without diabetes and the group in a pre-diabetic state, the effect was more pronounced in the group with diabetes.Conclusions: Our findings suggest that there is a positive association between SII and sNfL. Furthermore, in comparison to individuals without diabetes and those in a pre-diabetic state, the positive association between SII and sNfL was more pronounced in individuals with diabetes. Further large-scale prospective studies are needed to confirm the association between SII and sNfL.

    Keywords: systemic immune-inflammation index, serum neurofilament light chain, Crosssectional study, NHANES, Neurological function

    Received: 14 Jun 2024; Accepted: 12 Aug 2024.

    Copyright: © 2024 Liu, Yang, Lu, Yang, Yuan, Hu and Tu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yue Tu, Nanjing University of Chinese Medicine, Nanjing, China

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