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REVIEW article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1432085
This article is part of the Research Topic Sleep Disorders and Cerebrovascular Diseases View all 5 articles

Prevalence, Incidence, and the Time Trends of Sleep-disordered Breathing among Patients with Stroke: A Systematic Review and Meta-analysis

Provisionally accepted
Xiaofeng Su Xiaofeng Su Shanshan Liu Shanshan Liu Cong Wang Cong Wang Yan Cai Yan Cai Yijing Li Yijing Li Dongmin Wang Dongmin Wang zhaofeng Fan zhaofeng Fan Yan Jiang Yan Jiang *
  • West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

The final, formatted version of the article will be published soon.

    Background: Recent studies have investigated the epidemiological burden of sleep-disordered breathing (SDB) in patients with stroke; however, the results have been inconsistent, and the temporal trends of SDB after stroke remain unclear.Objective: To perform a systematic review and meta-analysis of the prevalence and incidence of post-stroke SDB, evaluate demographic and clinical characteristic predictors of post-stroke SDB, and examine temporal trends in the overall burden of post-stroke SDB.We searched PubMed, MEDLINE, Embase, Web of Science, CINAHL, and the Cochrane Library for studies reporting the burden of SDB in stroke patients published between 1 January 2010 and 30 December 2023. Two researchers independently screened the records for eligibility, extracted the data, and assessed the quality of the studies. Data were analyzed using random effects meta-analyses, and sources of heterogeneity were explored using subgroup analyses and meta-regression analyses.Results: Out of the 8,799 references retrieved, none examined the incidence of SDB after stroke. However, 85 studies from 26 countries examined the prevalence of SDB and were included. The overall prevalence of SDB, mild SDB, and moderate to severe SDB were 60.0% (95% CI, 60.0%-70.0%), 30.0% (95% CI, 23.0%-37.0%), and 45.0% (95% CI, 33.0%-57.0%), respectively. Meta-regression revealed that sex (P<0.0001) and sample size (P<0.01) were sources of heterogeneity among the studies. The pooled overall prevalence of SDB remained stable over time.SDB is common in patients with stroke, and no reduction in the high prevalence of SDB has been observed over time, suggesting that early screening and prevention of post-stroke SDB still have not received sufficient attention. Moreover, additional studies investigating the incidence of this disease are needed to inform clinical practice.

    Keywords: sleep-disordered breathing, Stroke, Epidemiology, Systematic review, Meta-analysis, Meta-regression

    Received: 18 May 2024; Accepted: 06 Nov 2024.

    Copyright: © 2024 Su, Liu, Wang, Cai, Li, Wang, Fan and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yan Jiang, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China

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