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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1431727
This article is part of the Research Topic Blood-Based Cellular and Molecular Biomarkers in Acute Ischemic Stroke and Hemorrhagic Stroke - Volume II View all 3 articles

Systemic Immune Inflammation Index and Risk of Stroke: A Cross-sectional Study of the National Health and Nutrition Examination Survey 2005-2018

Provisionally accepted
Hua Xue Hua Xue 1Yuqi Zeng Yuqi Zeng 2Xinyang Zou Xinyang Zou 1Yongkun Li Yongkun Li 1*
  • 1 Department of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China
  • 2 Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    Background The incidence of stroke has increased globally, resulting in medical expenditures and social burdens over the past few decades. We aimed to explore the relationship between systemic immune inflammatory index (SII) and stroke using the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Methods Based on NHANES data, 902 stroke patients and 27,364 non-stroke patients were included in this study. SII was the independent variable and stroke was the dependent variable. Univariate and multivariate logistic regression analyses were used to explore the association between SII and stroke. Restricted cubic spline ( RCS ) method was used to test the nonlinear association between SII and stroke. Results Weighted logistic regression analysis showed a significant association between SII and stroke ( OR : 1.985 , 95 % CI : 1.245 ~ 3.166 , P = 0.004). The interaction test showed that the association between SII and stroke was not significant between strata (P > 0.05). A significant positive association between SII and stroke risk ( OR > 1 , P < 0.05) was observed in the crude model, model I and model II. RCS analysis showed no nonlinear positive association between SII and stroke risk after adjusting for all confounders. Conclusions Our study determined a nonlinear and positive association between SII and stroke. Given the inherent limitations of cross-sectional studies, further research is necessary to validate the causality of this association and to demystify the underlying mechanisms between inflammation and stroke.

    Keywords: NHANES, systemic immune inflammation index, Stroke, Logistic regression, Cross-sectional study

    Received: 12 May 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Xue, Zeng, Zou and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Yongkun Li, Department of Neurology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, Fujian Province, China

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