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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1425633
This article is part of the Research Topic Advances and controversies in ischemic stroke management: from prevention to diagnosis and acute treatment View all 78 articles

Association of Hemoglobin-to-Red Cell Distribution Width Ratio with the Three-month Outcomes in Patients with Acute Ischemic Stroke

Provisionally accepted
XIiaorui Xie XIiaorui Xie 1Keli He Keli He 2*ZHANG YAO ZHANG YAO 2Jianhua Wu Jianhua Wu 2
  • 1 Department of Neurology, Xiangya Changde Hospital, Changde, Hunan Province, China
  • 2 Department of Clinical Laboratory, Changde Hospital, Xiangya School of Medicine, Central South University (The first people’s hospital of Changde city), Changde, China

The final, formatted version of the article will be published soon.

    To explore the association of Hemoglobin-to-Red Cell Distribution Width Ratio (HRR) with the risk of three-month unfavorable outcomes in acute ischemic stroke (AIS).Methods: A secondary analysis was conducted based on a prospective cohort study. A total of 1,889 patients with AIS treated in South Korea from January 2010 to December 2016 were enrolled. Multivariable logistic regression was conducted to investigated the independent relationship between HRR and risk of three-month unfavorable outcomes in AIS. Fitted smoothing curves were used to determine non-linear correlations. The recursive method was employed to explore the turning point and build a two-piece linear regression model. In addition, a set of subgroup analyses were carried out to evaluate the relationship between HRR and risk of three-month unfavorable outcomes.: Multivariate analysis in which potential confounders were adjusted for indicated that the risk of unfavorable outcomes was reduced by 10% for each unit increased of HRR, [OR = 0.90, 95% CI: 0.84-0.96, P = 0.0024]. In addition, a non-linear relationship was observed between HRR and risk of three-month unfavorable outcomes, which had an inflection point of HRR was 10.57. The effect sizes and the confidence intervals on the left side of the inflection point were 0.83 (0.75, 0.91), P=0.0001. On the right side of the inflection point, no association was found between HRR and the risk of three-month unfavorable outcomes.This study demonstrates a negative association between HRR and risk of three-month unfavorable outcomes. The relationship between HRR and risk of three-month unfavorable outcomes is non-linear. The correlation is negative for HRR values less than 10.57. For, HRR higher than 10.57, HRR is not associated with the risk of three-month unfavorable outcomes.

    Keywords: Stroke, three-month outcomes, Hemoglobin-to-red cell distribution width ratio, nonlinearity, prognosis

    Received: 30 Apr 2024; Accepted: 29 Jul 2024.

    Copyright: © 2024 Xie, He, YAO and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Keli He, Department of Clinical Laboratory, Changde Hospital, Xiangya School of Medicine, Central South University (The first people’s hospital of Changde city), Changde, China

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