Skip to main content

PERSPECTIVE article

Front. Neurol.
Sec. Multiple Sclerosis and Neuroimmunology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1425046
This article is part of the Research Topic The diagnostic difficulties of immune-mediated neuropathies View all 9 articles

Diagnostic Potential of Blood-based Biomarkers in Multiple Sclerosis

Provisionally accepted

The final, formatted version of the article will be published soon.

    Multiple Sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system (CNS). There is a significant delay in diagnosing MS, as the symptoms and tests share overlap with other diseases. Blood-based biomarker, quantifying fragments of proteins involved in MS pathophysiology, holds the potential as diagnostic biomarkers. In this study, we evaluated biomarkers by immunoassays, of tissue destruction, reflected by biglycan degraded by matrix metalloproteinases (MMPs) (BGM), Cathepsin S-degraded nidogen (NIC), and MMP-degraded SPARC (SPARC-M) BGM, NIC and SPARC-M in healthy donors and patients diagnosed with MS. The biomarkers were able to separate the two groups with an AUC=0.710, AUC=0.765, and AUC=0.875, respectively. These pathologically released protein fragments could potentially be used as biomarkers in clinical management, provided a specific fingerprint can be determined.

    Keywords: biomarkers, Multiple Sclerosis, Proteins, diagnosis, Blood bimarkers

    Received: 29 Apr 2024; Accepted: 13 Nov 2024.

    Copyright: © 2024 Holm Nielsen, Karsdal, Manoel, Bay-Jensen and Henriksen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Signe Holm Nielsen, Nordic Bioscience (Denmark), Herlev, Denmark

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.