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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Dementia and Neurodegenerative Diseases
Volume 15 - 2024 |
doi: 10.3389/fneur.2024.1422681
CAPS: A simple clinical tool for β-amyloid positivity prediction in clinical Alzheimer Syndrome
Provisionally accepted- 1 University of Toronto, Toronto, Canada
- 2 Rotman Research Institute (RRI), Toronto, Ontario, Canada
- 3 Baycrest Hospital, Toronto, Ontario, Canada
With the advent of anti-β-amyloid therapies, clinical distinction between Aβ+ and Aβ-in cognitive impairment is becoming increasingly important for stratifying referral and better utilization of biomarker assays. METHODS: Cognitive profile, rate of decline, neuropsychiatric inventory questionnaire (NPI-Q) and imaging characteristics were collected from 52 subjects with possible/ probable AD. RESULTS: Participants with Aβ+ status had lower baseline MMSE scores (24.50 vs 26.85, p=0.009) and higher total NPI-Q scores (2.73 vs 1.18, p<.001). NPI-Q score was found to be the only independent predictor for β-amyloid positivity (p=.008). A simple scoring system, namely CAPS, was developed by using the following parameters: NPI-Q, rapidity of cognitive decline, and white matter microangiopathy. Data from 48 participants were included in the analysis of accuracy of CAPS. CAP Score of 3 or 4 successfully classified Aβ+ individuals in 86.7% cases. DISCUSSION: CAPS is a simple clinical tool for use in primary care and memory clinic settings to predict β-amyloid positivity in individuals with clinical Alzheimer Syndrome can potentially facilitate referral for Anti Aβ therapies.
Keywords: Alzheimer, clinical, CAPS, early diagnosis, Amyloid - beta
Received: 24 Apr 2024; Accepted: 29 Jul 2024.
Copyright: © 2024 Lahiri, Seixas-Lima, Roncero, Verhoeff, FReedman, Al-Shaama and Chertkow. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Howard Chertkow, University of Toronto, Toronto, Canada
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