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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Stroke
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1420915
This article is part of the Research Topic Advances and controversies in ischemic stroke management: from prevention to diagnosis and acute treatment View all 79 articles

Clinical Value of Thromboelastography in Predicting the Risk of Recurrence of Acute Ischemic Stroke

Provisionally accepted
Ruyue Guo Ruyue Guo 1,2Xiaoming Shen Xiaoming Shen 2*Jin Lu Jin Lu 1,2*Zhou Jiao Zhou Jiao 1,2Shinan Hao Shinan Hao 1,2*Rui Lan Rui Lan 2*Yu-Min Xu Yu-Min Xu 2
  • 1 第一临床医学院, Henan University of Chinese Medicine, Zhengzhou, China
  • 2 Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China

The final, formatted version of the article will be published soon.

    Ethical review consent letter：Approval number: 2022HL-088-01.【Abstract】 BackgroundThromboelastography (TEG) can objectively reflect the formation, development and rupture process of thrombosis in patients, but there are limited data on whether TEG can be used as a predictive tool for recurrence in patients with acute ischemic stroke. Objective To explore the TEG risk of recurrence in patients with acute ischemic stroke predictive value.Methods: A total of 441 patients with acute ischemic stroke who met the research criteria in the First Affiliated Hospital of Henan University of Traditional Chinese Medicine from January 2020 to December 2021 were selected as the research objects. TEG was measured in all patients, and the main parameters of TEG (R value, indicating coagulation reaction time; K value and Angle, the rate of blood clot formation; MA value, indicating the maximum amplitude). The primary outcome of this study was ischemic stroke recurrence. Recurrent events included cerebral infarction, cerebral hemorrhage, TIA, and were determined by combining imaging events and clinical events. Logistic regression analysis was used to explore the influencing factors of recurrence in patients with acute ischemic stroke. Results Fifty-six patients (12.7%) had recurrence.Multivariate Logistic regression analysis showed that: Age [OR=1.078, 95%CI(1.024, 1.135)], triglyceride [OR=1.541, 95%CI(1.033, 2.298)], glycosylated hemoglobin [OR=1.401, 95%CI(1.097, 1.790)], history of hypertension [OR=16.046, P < 0.05], 95%CI(4.726, 54.489), R value [OR=0.533, 95%CI(0.351, 0.809)], MA value [OR=1.399, 95%CI(1.004, 1.949)] were independent influencing factors for hemorrhagic transformation in patients with acute ischemic stroke. Conclusions TEG has some value in predicting recurrence in patients with acute ischemic stroke, and the MA value in TEG [AUC=0.806(95%CI:0.747-0.867), with a sensitivity of 78.6% and a specificity of 70.4%], predicted the most significant efficiency of AIS recurrence.

    Keywords: Thromboelastography, Recurrent stroke, Influencing factors analysis, Predictive Value, Acute ischemic stroke (AIS

    Received: 21 Apr 2024; Accepted: 30 Jul 2024.

    Copyright: © 2024 Guo, Shen, Lu, Jiao, Hao, Lan and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Xiaoming Shen, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
    Jin Lu, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
    Shinan Hao, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China
    Rui Lan, Center of Encephalopathy, First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan Province, China

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