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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuroepidemiology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1420675

Opioid Use Disorder and Intracerebral Hemorrhage in Isfahan, Iran: A Case-Control Study

Provisionally accepted
Mohammad Saadatnia Mohammad Saadatnia Razieh Norouzi Razieh Norouzi Mohammad Amin Najafi Mohammad Amin Najafi Sahand Gol Parvar Sahand Gol Parvar Arash Najafian Arash Najafian Aryan Tabatabei Aryan Tabatabei Melika Foroughi Melika Foroughi Sadaf Esteki Sadaf Esteki Fariborz Khorvash Fariborz Khorvash *
  • Isfahan University of Medical Sciences, Isfahan, Iran

The final, formatted version of the article will be published soon.

    Background: Opium use disorder is a significant health problem in our country, leading to a considerable number of health issues. Opium has several detrimental effects on its consumers. However, the effect of Opium use disorder on intracerebral hemorrhage (ICH) has not been evaluated. This study aims to evaluate the relationship between Opium use disorder and ICH.In this case-control study, 402 patients with ICH and 404 patients without ICH enrolled. Opium use disorder, other vascular risk factors including diabetes mellitus, hypertension, hyperlipidemia, and tobacco smoking was compared between these groups. Patients with ICH were divided into two groups; first group are patients with history of opioid use disorder and second group are those patients without opioid use disorder. ICH features including clinical and imaging characteristics and prognostic findings were compared between patients with and without Opium use disorder.Results: This case-control study of 806 participants found that hypertension (OR=6.84, 95% CI: 5.03-9.34, p-value: <0.001), Opium use disorder (OR=4.23, 95% CI: 2.42-7.35, p-value: <0.001) and tobacco smoking (OR=1.47, 95% CI: 1.01-2.16, p-value: 0.049) had a higher risk of ICH. Opium-addicted subjects had higher ICH scores (2.61±1.27 vs. 2.11±1.29, p-value: 0.005), were more likely to have infratentorial hemorrhage (22% vs. 12%, OR=2.13, 95% CI: 1.06-4.28, pvalue: 0.038), more likely to be intubated (66% vs. 54%, OR=1.79, 95% CI: 0.98-3.27, p-value= 0.041) and had lower GCS scores (9.58±3.60 vs. 8.25±3.88, p-value: 0.01). The effect of Opium use disorder independently on ICH was also shown in logistic regression (adjusted OR=3.15, p-value=0.001).This study is the first to evaluate the effect of Opium use disorder on ICH, identifying Opium use disorder as a new potential risk factor for ICH.

    Keywords: opioid, Life Style, intracerebral hemorrhage (ICH), Opium abuse, Case-Control Analysis

    Received: 20 Apr 2024; Accepted: 30 Aug 2024.

    Copyright: © 2024 Saadatnia, Norouzi, Najafi, Gol Parvar, Najafian, Tabatabei, Foroughi, Esteki and Khorvash. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Fariborz Khorvash, Isfahan University of Medical Sciences, Isfahan, Iran

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