AUTHOR=Cai Zehao , Yang Zukai , Wang Ying , Li Ye , Zhao Hong , Zhao Hanwen , Yang Xue , Wang Can , Meng Tengteng , Tong Xiao , Zheng Hao , He Zhaoyong , Niu Chunli , Yang Junzhi , Chen Feng , Yang Zhi , Zou Zhige , Li Wenbin 

TITLE=Tumor treating induced fields: a new treatment option for patients with glioblastoma

JOURNAL=Frontiers in Neurology

VOLUME=15

YEAR=2024

URL=https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2024.1413236

DOI=10.3389/fneur.2024.1413236

ISSN=1664-2295

ABSTRACT=<sec id="sec1"><title>Purpose</title><p>Currently, a range of electromagnetic therapies, including magnetic field therapy, micro-currents therapy, and tumor treating fields, are under investigation for their potential in central nervous system tumor research. Each of these electromagnetic therapies possesses distinct effects and limitations. Our focus is on overcoming these limitations by developing a novel electric field generator. This generator operates by producing alternating induced currents within the tumor area through electromagnetic induction.</p></sec><sec id="sec2"><title>Methods</title><p>Finite element analysis was employed to calculate the distribution of electric fields. Cell viability was assessed using the CCK-8 assay. Tumor volumes and weights served as indicators to evaluate the effectiveness of TTIF. The <italic>in-vivo</italic> imaging system was utilized to confirm tumor growth in the brains of mice.</p></sec><sec id="sec3"><title>Results</title><p>TTIF significantly inhibited the proliferation of U87 cells both <italic>in vitro</italic> and <italic>in vivo</italic>.</p></sec><sec id="sec4"><title>Conclusion</title><p>TTIF significantly inhibited the proliferation of U87 cells both <italic>in vitro</italic> and <italic>in vivo</italic>. Consequently, TTIF emerges as a potential treatment option for patients with progressive or metastatic GBM.</p></sec>