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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1412471

Association between hypertension requiring medication and postoperative 30-day mortality in adult patients with tumour craniotomy: An analysis of data using propensity score matching

Provisionally accepted
Yufei Liu Yufei Liu 1*Haofei Hu Haofei Hu 2Wenjian Zheng Wenjian Zheng 1Zhong Deng Zhong Deng 1Jihu Yang Jihu Yang 1Xiejun Zhang Xiejun Zhang 1Zongyang Li Zongyang Li 1Lei Chen Lei Chen 1Fanfan Chen Fanfan Chen 1Nan Ji Nan Ji 3Guodong Huang Guodong Huang 1*
  • 1 Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, China
  • 2 Shenzhen Second People's Hospital, Shenzhen, Guangdong Province, China
  • 3 Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China

The final, formatted version of the article will be published soon.

    Background: Reliable quantification of the association between hypertension requiring medication and postoperative 30-day mortality in adult patients who undergo craniotomy for tumour resection is limited. We aimed to explore the associations between these factors.This work was a retrospective cohort study that used propensity score matching (PSM) among 18,642 participants from the American College of Surgeons National Surgical Quality Improvement Program database between 2012 and 2015. Hypertension requiring medication and postoperative 30-day mortality were the independent and dependent target variables, respectively.PSM was conducted via nonparsimonious multivariate logistic regression to balance the confounders.Robust estimation methods were used to investigate the association between hypertension requiring medication and postoperative 30-day mortality.Results: A total of 18,642 participants (52.6% male and 47.4% female) met our inclusion criteria; 7,116 (38.17%) participants with hypertension required medication and had a 3.74% mortality rate versus an overall mortality rate of 2.46% in the adult cohort of patients who underwent craniotomy for tumour resection. In the PSM cohort, the risk of postoperative 30-day mortality significantly increased by 39.0% among patients with hypertension who required medication (OR=1.390, 95% confidence interval (CI): 1.071-1.804, P=0.01324) after adjusting for the full covariates. Compared with participants without hypertension requiring medication, those with hypertension requiring medication had a 34.0% greater risk of postoperative 30-day mortality after adjusting for the propensity score (OR=1.340, 95% CI: 1.040-1.727, P=0.02366) and a 37.6% greater risk of postoperative 30-day mortality in the inverse probability of treatment weights (IPTW) cohort (OR=1.376, 95% CI: 1.202, 1.576, P<0.00001).Conclusion: Among U.S. adult patients undergoing craniotomy for tumour resection, hypertension requiring medication is a notable contributor to 30-day mortality after surgery, with odds ratios ranging from 1.34 to 1.39.

    Keywords: brain tumour, Craniotomy, Hypertension, Propensity score matching, Mortality

    Received: 05 Apr 2024; Accepted: 06 Sep 2024.

    Copyright: © 2024 Liu, Hu, Zheng, Deng, Yang, Zhang, Li, Chen, Chen, Ji and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Yufei Liu, Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, China
    Guodong Huang, Department of Neurosurgery, Shenzhen Second People's Hospital, Shenzhen, China

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