Skip to main content

ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neurological Biomarkers
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1410569
This article is part of the Research Topic Neuro-Imaging in Intracerebral Hemorrhage: Updates and Knowledge Gaps View all 7 articles

Association between serum osmolality and risk of in-hospital mortality in patients with intracerebral hemorrhage

Provisionally accepted
Zhaosuo Hu Zhaosuo Hu Quan Sha Quan Sha *
  • Anhui Medical University, Hefei, Anhui Province, China

The final, formatted version of the article will be published soon.

    Aim: This study aimed to analyze the association between serum osmolality and the risk of in-hospital mortality in intracerebral hemorrhage (ICH) patients. Methods: In this cohort study, a total of 1837 ICH patients aged ≥18 years from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) were identified. Serum osmolality and blood urea nitrogen (BUN) to creatinine (Cr) ratio (BCR) were used as the main variables to analyze their association with the risk of in-hospital mortality in ICH patients after first intensive care unit (ICU) admission, and univariate Cox model was established. Univariable and multivariable Cox regression analysis were applied to explore the associations among serum osmolality and BCR with the in-hospital mortality of ICH patients. Hazard ratio (HR), and 95% confidence interval (CI) were calculated. Results: The median survival time of all participants was 8.29 (4.61-15.24) days. Serum osmolality ≥295 mmol/L was correlated with increased risk of in-hospital mortality in patients with ICH (HR=1.43, 95%CI: 1.14-1.78). BCR >20 was not significantly associated with the risk of in-hospital mortality in patients with ICH. Subgroup analysis indicated that increased risk of in-hospital mortality was found in ICH patients who were females, White, Black, or complicated with acute kidney injury (AKI). Conclusion: High serum osmolality was related to increased risk of in-hospital mortality in patients with ICH.

    Keywords: intracerebral hemorrhage, In-hospital mortality, Serum osmolality, ICU, blood urea nitrogen to creatinine ratio

    Received: 01 Apr 2024; Accepted: 24 Jun 2024.

    Copyright: © 2024 Hu and Sha. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Quan Sha, Anhui Medical University, Hefei, 230032, Anhui Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.