Skip to main content

CLINICAL TRIAL article

Front. Neurol.
Sec. Experimental Therapeutics
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1410531
This article is part of the Research Topic Advancements in Surgical Strategies and Technologies for Cranial Nerve Disorders View all 3 articles

Management of Meige syndrome with Bilateral Trigeminal and Facial Nerves Combing

Provisionally accepted
Tingting Ying Tingting Ying 1,2Haopeng Wang Haopeng Wang 1,2*Yinda Tang Yinda Tang 1,2*Hua Zhao Hua Zhao 1,2Xiaomin Cai Xiaomin Cai 1,2Yiman Shen Yiman Shen 1,2*Baimiao Wang Baimiao Wang 1,2*Wanchun Zhu Wanchun Zhu 1,2*Ping Zhou Ping Zhou 1,2*Xin Zhang Xin Zhang 1,2*Jun Zhong Jun Zhong 1,2WANG XINJUN WANG XINJUN 3,4Xudong Fu Xudong Fu 3,4Jin Zhu Jin Zhu 1,2*Weituo Zhang Weituo Zhang 5*Shiting Li Shiting Li 1,2*
  • 1 Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, Shanghai Municipality, China
  • 2 Cranial Nerve Disease Diagnosis and Treatment Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  • 3 Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
  • 4 Institute of Neuroscience, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan Province, China
  • 5 Hongqiao International Medical Research Institute, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China

The final, formatted version of the article will be published soon.

    Objective: Meige syndrome (MS) is an adult-onset segmental dystonia and there is no satisfactory remedy for this syndrome. Our team developed a novel surgical approach named bilateral trigeminal/facial nerves combing (BTFC). This study aimed to evaluate the outcome of those patients following BFTC (Clinical trial registry number: ChiCTR2000033481). Method: We assigned 22 patients who had MS to undergo BTFC. Primary outcome was the movements subscale of Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-M) at month 12 postoperatively. Second outcome was evaluated by Mos 36-item Short Form Health Survey (SF-36), dysfunction of Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS-D), and subitem scores of BFMDRS-M. Safety outcomes was the House Brackmann (HB) functional grading score and Visual analogue scale (VAS) of facial numbness.At the final follow-up of 12 months, the BFMDRS-M showed a mean improvement of 70.7% from baseline. Mean scores of the BFMDRS-M submotor (including eyes, mouth, and speech/swallowing) improved by 65.6%, 81.00%, and 60%, respectively. The median score of the total BFMDRS-D score were 0.70±1.17 compared with 1.86±2.21 at baseline. There were no serious operative complications in this population. The quality of life of the patients was significantly improved (P＜0.05).Conclusions BFTC demonstrated to be effective in relieving the symptoms of Meige syndrome and provided a new alternative treatment for patients who have failed to respond to medications, botulinum toxin injections and DBS.

    Keywords: Meige Syndrome, combing, trigeminal nerves, Facial Nerve, BFMDRS-M

    Received: 01 Apr 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Ying, Wang, Tang, Zhao, Cai, Shen, Wang, Zhu, Zhou, Zhang, Zhong, XINJUN, Fu, Zhu, Zhang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haopeng Wang, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Yinda Tang, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Yiman Shen, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Baimiao Wang, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Wanchun Zhu, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Ping Zhou, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Xin Zhang, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Jin Zhu, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China
    Weituo Zhang, Hongqiao International Medical Research Institute, Tongren Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200336, China
    Shiting Li, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200092, Shanghai Municipality, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.