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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Sleep Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1408890
This article is part of the Research Topic Central Nervous System Diseases and Anesthesia View all 4 articles

Exploring Bispectral Index as an Alternative to Polysomnography for Long-Term Sleep Monitoring in Disorders of Consciousness

Provisionally accepted
Ge Qianqian Ge Qianqian 1Kaitian Chen Kaitian Chen 1,2Qinghua Li Qinghua Li 3Yutong zhuang Yutong zhuang 1Peijian Sun Peijian Sun 1Long Xu Long Xu 1*Jianghong He Jianghong He 4*
  • 1 Beijing Tiantan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 2 Southern Medical University, Guangzhou, Guangdong, China
  • 3 Beijing Ditan Hospital, Capital Medical University, Beijing, Beijing Municipality, China
  • 4 Department of Neurosurgery，Beijing Tiantan Hospital, Capital Medical University, Beijing, China

The final, formatted version of the article will be published soon.

    Sleep plays a crucial role in neuroplasticity and recovery from brain injury, particularly in disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS). Traditional sleep monitoring methods like polysomnography (PSG) are complex and often impractical for long-term use in clinical settings. This study aimed to explore the utility of the Bispectral Index (BIS) as a more practical alternative for monitoring sleep patterns in DoC patients. We conducted simultaneous PSG and BIS monitoring on 38 DoC patients (19 UWS and 19 MCS). The study focused on analyzing sleep timing distribution, the effectiveness of BIS in differentiating sleep stages, and its correlation with consciousness levels. Our findings revealed that DoC patients exhibited irregular and fragmented sleep patterns, necessitating extended monitoring periods. The BIS effectively differentiated various sleep stages, with significant differences in BIS values observed across these stages. However, BIS values did not show significant differences between UWS and MCS patients, indicating that BIS primarily indicates wakefulness rather than cognitive awareness. DoC patients have disturbed sleep-wake cycles that require prolonged monitoring. BIS can well distinguish sleep stages in DoC patients, and the distribution of values is similar to that of normal subjects. However, BIS could not distinguish the level of consciousness of DoC patients. The study demonstrates the potential of BIS as a practical tool for long-term sleep monitoring in DoC patients, offering a less intrusive alternative to traditional methods.

    Keywords: disorders of consciousness (DOC), Bispectral index (BIS), electroencephalographic (EEG), Sleep monitoring, Sleep

    Received: 04 Apr 2024; Accepted: 23 Sep 2024.

    Copyright: © 2024 Qianqian, Chen, Li, zhuang, Sun, Xu and He. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Long Xu, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, Beijing Municipality, China
    Jianghong He, Department of Neurosurgery，Beijing Tiantan Hospital, Capital Medical University, Beijing, China

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