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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Headache and Neurogenic Pain
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1407243

Association between the composite dietary antioxidant index and severe headache or migraine: results from the National Health and Nutrition Examination Survey

Provisionally accepted
Zhiru Zhang Zhiru Zhang 1Xushan Chen Xushan Chen 2Haotao Fang Haotao Fang 1*Jiechao Ye Jiechao Ye 1*Xiaona Tang Xiaona Tang 2*Rucheng Huang Rucheng Huang 3*
  • 1 Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen City, China
  • 2 Shenzhen Bao’an District Traditional Chinese Medicine Hospital, Shenzhen, China
  • 3 Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China

The final, formatted version of the article will be published soon.

    Background: Severe headache or migraine is a neurological disease that seriously affects the quality of human life. Oxidative stress is considered a main factor in the pathogenesis of severe headache or migraine. The Composite Dietary Antioxidant Index (CDAI) is a score calculated using six dietary antioxidant components (including vitamins A, C, E, selenium, zinc, and carotenoid), which represents a person's level of dietary antioxidant ingredients. Based on the theory of oxidative stress, we speculated that CDAIs may be relevant to the risk of severe headache or migraine, as the relationship between the CDAI and severe headache or migraine is unclear. Hence, the purpose of this study was to explore the relationship between the CDAI and severe headache or migraine in participants. Methods: We performed a cross-sectional study using data from the National Health and Nutrition Examination Survey (NHANES) that were collected from 2001 to 2004. A total of 4,943 participants were included, of whom 1,232 experienced severe headaches or migraines. Participants' CDAIs were calculated based on their intake of six dietary antioxidants. We used logistic regression models, limited cubic spline analysis, and subgroup analysis to assess the association of CDAI with severe headache or migraine. Results: The multivariate logistic regression model, (correcting for all potential covariates) revealed that the odds ratio (95% Confidence lnterval [CI]) for the association between CDAI and severe headache or migraine was 0.97 (95% CI = 0.95-1.00, p = 0.048).Compared with individuals with low CDAIs in Quartile (Q)1, the adjusted Odds Ratio between the CDAI and severe headache or migraine in Q2, Q3, and Q4 were 0.84 (95% CI = 0.69-1.01, p = 0.07), 0.77 (95% CI = 0.63-0.96, p = 0.017), and 0.73 (95% CI = 0.56-0.95, p = 0.02), respectively.Restricted cubic spline regression analysis showed an L-shaped relationship between the CDAI and

    Keywords: composite dietary antioxidant index (CDAI), Migraine, Severe headache, Oxidative Stress, Cross-sectional study

    Received: 26 Mar 2024; Accepted: 15 Jul 2024.

    Copyright: © 2024 Zhang, Chen, Fang, Ye, Tang and Huang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Haotao Fang, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen City, China
    Jiechao Ye, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Shenzhen City, China
    Xiaona Tang, Shenzhen Bao’an District Traditional Chinese Medicine Hospital, Shenzhen, 518133, China
    Rucheng Huang, Seventh Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China

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