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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neurotrauma
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1407107
This article is part of the Research Topic Differentiating and understanding the multifaceted nature of Traumatic Brain Injury using clinical and pre-clinical systems View all 5 articles

The association between early coagulation disorder and the risk of severe acute kidney injury in traumatic brain injury patients: a retrospective cohort study of MIMIC-IV database

Provisionally accepted
Yu Gao Yu Gao Yong Li Yong Li Hai Zhou Hai Zhou Xin Wang Xin Wang Guojun Wang Guojun Wang Lin Zhu Lin Zhu *
  • Binhai County People's Hospital, Yancheng, China

The final, formatted version of the article will be published soon.

    Aim: Acute kidney injury (AKI) and coagulation disorder, two common complications of traumatic brain injury (TBI), are associated with the poor prognosis. However, the association between early coagulation disorder and the risk of severe AKI in TBI patients remains elusive. This study aimed to explore the association between early coagulation disorder and the risk of severe AKI in TBI patients admitted to the intensive care units (ICU).In this retrospective cohort study, adults diagnosed as TBI were extracted from the MIMIC IV database. The outcome was the risk of severe AKI within 7 days of ICU admission among TBI patients. Covariates included sociodemographic information, vital signs, scoring systems and laboratory parameters were extracted from the database. The univariable and multivariable COX proportional hazard regression models were used to assess the association between early coagulation disorder and the risk of severe AKI within 7 days of admission to ICU in TBI patients. Subgroup analyses based on age and Glasgow Coma Scale (GCS) score were further assessed the association.Results: A total of 846 patients were finally included, of which 187 (22.10%) had severe AKI. After adjusted all covariates, TBI patients with early coagulation disorder had a higher risk of developing to severe AKI within 7 days of ICU admission than TBI patients without early coagulation disorder (HR=1.40, 95%CI: 1.04-1.89), especially among TBI patients aged ≥ 65 years old (HR=1.46, 95%CI: 1.01-2.04) and GCS score ≤ 13 (HR=1.91, 95%CI: 1.16-3.15).In TBI patients, ones with early coagulation disorder had a high risk of developing to severe AKI within 7 days of ICU admission, which would be a promising biomarker and helpful for the management of kidney health in TBI patients.

    Keywords: Early coagulation disorder, Acute Kidney Injury, Traumatic Brain Injury, MIMIC-IV database, Retrospective cohort study

    Received: 26 Mar 2024; Accepted: 24 Dec 2024.

    Copyright: © 2024 Gao, Li, Zhou, Wang, Wang and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Lin Zhu, Binhai County People's Hospital, Yancheng, China

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