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REVIEW article

Front. Neurol.
Sec. Neuro-Otology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1406617
This article is part of the Research Topic Function of Vestibular and Auditory Systems in Neurogenerative Disorders View all 5 articles

Measurement of traveling wave velocity in the basilar membrane may detect endolymphatic hydrops in definite Mé niè re's Disease: A Narrative Review

Provisionally accepted
Xingqian Shen Xingqian Shen 1Hui Pan Hui Pan 1Wen Xie Wen Xie 1Linlin Wang Linlin Wang 1Yangming Leng Yangming Leng 1Bo Liu Bo Liu 2*Hongjun Xiao Hongjun Xiao 1*
  • 1 Department of Otorhinolaryngology-Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China
  • 2 Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

The final, formatted version of the article will be published soon.

    The pathological hallmark of Mé niè re's disease is endolymphatic hydrops, which can lead to an increase in basilar membrane stiffness and, consequently, an acceleration of the traveling wave of sound. The cochlear hydrops analysis masking procedure (CHAMP), which is an auditory brainstem response test masked at various frequencies with high-pass noise masking, uses the principle of the traveling wave velocity theory to determine the presence of endolymphatic hydrops.Purpose: To review the previous results of the CHAMP, expound the principle and key indicator of this procedure, and discuss its clinical significance in diagnosing Mé niè re's disease.Methods: A narrative review was performed, revisiting the principles of the CHAMP test, its procedures, and the results of its clinical application in diagnosing Mé niè re's disease.According to the published literature, CHAMP has a specificity of 31% to 100%, a sensitivity of 28% to 100%, and a diagnostic accuracy of 30% to 100% for the diagnosis of Mé niè re's disease, including patients with definite, probable, or possible Mé niè re's disease in various studies. These inconsistent results were due to subject inclusion criteria, variable settings, waveform identification, and other factors. Nevertheless, as an electrophysiological technique, CHAMP may have a relatively high diagnostic value in patients with a definite Mé niè re's disease.Conclusions: CHAMP is still potentially useful for studying the pathophysiology of hydropic ear diseases since the procedure can measure the traveling wave velocity of the basilar membrane in the era of imaging to detect endolymphatic hydrops for Mé niè re's disease.

    Keywords: Ménière's disease, cochlear hydrops analysis masking procedure, Traveling wave velocity, Diagnoses, Endolymphatic Hydrops

    Received: 25 Mar 2024; Accepted: 29 Nov 2024.

    Copyright: © 2024 Shen, Pan, Xie, Wang, Leng, Liu and Xiao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Bo Liu, Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Hongjun Xiao, Department of Otorhinolaryngology-Head and Neck Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hebei Province, China

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