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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Sleep Disorders
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1400810

Cerebral Blood Flow in Paracentral Lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment

Provisionally accepted
Jiaxue Sun Jiaxue Sun 1*Yi Lu Yi Lu 2Deshenyue Kong Deshenyue Kong 2Wenhua Lin Wenhua Lin 3*Jinze Du Jinze Du 3*Guangqin Wang Guangqin Wang 4*Xingfeng Ma Xingfeng Ma 4*Congbin Li Congbin Li 4*Kunhua Wang Kunhua Wang 3*Mei Zhu Mei Zhu 2*Yu Xu Yu Xu 2*
  • 1 kunming medial University, Kunming, China
  • 2 The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
  • 3 Yunnan University, Kunming, Yunnan Province, China
  • 4 Drug Rehabilitation Administration of Yunnan Province, Kunming, China

The final, formatted version of the article will be published soon.

    Introduction: Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), leading to a detrimental impact on their quality of life and treatment adherence. Cerebral blood flow (CBF) plays a crucial role in the development of various diseases ; however, but its' relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in methadone maintenance treatment (MMT)patients.Methods: A total of 75 participants with a history of MMT were recruited and assessed with pseudocontinuous arterial spin labeling magnetic resonance imaging. CBF was ascertained using pseudocontinuous arterial spin labeling magnetic resonance imaging. LAASO regression model were conducted to pick out the Region-of-interest (ROI) most associated with sleep disturbance. The sleep quality 删除: in 删除: ndergoing 删除: onset and progression of numerous diseases 删除: the association between CBF and 删除: To understanding the neurobiological mechanisms linkingof sleep disturbance in methadone maintenance treatment (MMT) MMT patients.

    Keywords: Arterial Spin Labeling, cerebral blood flow (CBF), methadone maintenance treatment (MMT), Paracentral lobule, Sleep disturbance

    Received: 23 Mar 2024; Accepted: 23 Jul 2024.

    Copyright: © 2024 Sun, Lu, Kong, Lin, Du, Wang, Ma, Li, Wang, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence:
    Jiaxue Sun, kunming medial University, Kunming, China
    Wenhua Lin, Yunnan University, Kunming, 650500, Yunnan Province, China
    Jinze Du, Yunnan University, Kunming, 650500, Yunnan Province, China
    Guangqin Wang, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
    Xingfeng Ma, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
    Congbin Li, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
    Kunhua Wang, Yunnan University, Kunming, 650500, Yunnan Province, China
    Mei Zhu, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
    Yu Xu, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.