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ORIGINAL RESEARCH article
Front. Neurol.
Sec. Sleep Disorders
Volume 15 - 2024 |
doi: 10.3389/fneur.2024.1400810
Cerebral Blood Flow in Paracentral Lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment
Provisionally accepted- 1 kunming medial University, Kunming, China
- 2 The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
- 3 Yunnan University, Kunming, Yunnan Province, China
- 4 Drug Rehabilitation Administration of Yunnan Province, Kunming, China
Introduction: Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), leading to a detrimental impact on their quality of life and treatment adherence. Cerebral blood flow (CBF) plays a crucial role in the development of various diseases ; however, but its' relationship with sleep disorders remains uncertain. This observational study focuses on possible correlations between CBF and poor subjective sleep quality in methadone maintenance treatment (MMT)patients.Methods: A total of 75 participants with a history of MMT were recruited and assessed with pseudocontinuous arterial spin labeling magnetic resonance imaging. CBF was ascertained using pseudocontinuous arterial spin labeling magnetic resonance imaging. LAASO regression model were conducted to pick out the Region-of-interest (ROI) most associated with sleep disturbance. The sleep quality 删除: in 删除: ndergoing 删除: onset and progression of numerous diseases 删除: the association between CBF and 删除: To understanding the neurobiological mechanisms linkingof sleep disturbance in methadone maintenance treatment (MMT) MMT patients.
Keywords: Arterial Spin Labeling, cerebral blood flow (CBF), methadone maintenance treatment (MMT), Paracentral lobule, Sleep disturbance
Received: 23 Mar 2024; Accepted: 23 Jul 2024.
Copyright: © 2024 Sun, Lu, Kong, Lin, Du, Wang, Ma, Li, Wang, Zhu and Xu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Jiaxue Sun, kunming medial University, Kunming, China
Wenhua Lin, Yunnan University, Kunming, 650500, Yunnan Province, China
Jinze Du, Yunnan University, Kunming, 650500, Yunnan Province, China
Guangqin Wang, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
Xingfeng Ma, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
Congbin Li, Drug Rehabilitation Administration of Yunnan Province, Kunming, China
Kunhua Wang, Yunnan University, Kunming, 650500, Yunnan Province, China
Mei Zhu, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
Yu Xu, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan Province, China
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