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ORIGINAL RESEARCH article

Front. Neurol.
Sec. Neuroepidemiology
Volume 15 - 2024 | doi: 10.3389/fneur.2024.1392275

Elevated neopterin and decreased IL-4, BDNF levels and depression in lymphoma patients receiving R-CHOP chemotherapy

Provisionally accepted
Pinki Mishra Pinki Mishra 1Dinesh Bhurani Dinesh Bhurani 2Nidhi . Nidhi . 3*
  • 1 School of Chemical & Life Sciences, Jamia Hamdard University, New Delhi, India
  • 2 Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, National Capital Territory of Delhi, India
  • 3 Jamia Hamdard University, New Delhi, India

The final, formatted version of the article will be published soon.

    Objective: Depression is the most commonly observed psychological manifestation experienced by individuals diagnosed with cancer. The purpose of the study was to investigate the association between levels of IL-4, BDNF, neopterin, and depressive symptoms in lymphoma patients receiving consecutive cycles of chemotherapy.Newly diagnosed lymphoma patients scheduled to receive R-CHOP chemotherapy were enrolled. Effects of R-CHOP on circulatory biomarkers and depressive symptoms were assessed at three-time points (baseline assessment seven days before the first dose of chemotherapy (TP1), interim assessment after the third cycle of chemotherapy (TP2), and follow-up assessment after the 6th cycle of chemotherapy (TP3).Results: Seventy lymphoma patients, with a mean age of 44.17±13.67 years, were enrolled.Patients receiving R-CHOP were found significantly increased neopterin levels between given time points TP1 vs TP2, TP1 vs TP3, and TP2 vs TP3 (p<0.001). However, IL-4 and BDNF levels significantly decreased with consecutive cycles of chemotherapy (p<0.001). On Patient Health Questionnaire assessment (PHQ-9), scores of items like loss of interest, feeling depressed , sleep problems, loss of energy , and appetite problems were found significantly affected with consecutive cycles of chemotherapy (p<0.001). The study found weak negative correlations between IL-4, BDNF, and neopterin levels and changes in PHQ-9 scores at both TP2 and TP3, suggesting a potential inverse relationship between these markers and depression symptoms. Conclusion: In conclusion, the present study suggests a potential link between elevated neopterin levels, decreased IL-4, and BDNF levels,and the presence of depression in lymphoma patients receiving R-CHOP chemotherapy. This study provides valuable insights into understanding the emotional challenges faced by cancer patients, offering information for more personalized interventions and comprehensive support approaches within the oncology setting.

    Keywords: Depression, PHQ-9, BDNF, IL-4, Neopterin, Lymphoma, chemotherapy

    Received: 27 Feb 2024; Accepted: 02 Sep 2024.

    Copyright: © 2024 Mishra, Bhurani and .. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Nidhi ., Jamia Hamdard University, New Delhi, India

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